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DEVELOPMENTAL ORIGINS OF CARDIOVASCULAR DISEASE: ATRIAL NATRIURETIC PEPTIDE GENE DISRUPTED MICE AS A MODEL OF GESTATIONAL HYPERTENSION
Introduction: Developmental origins of disease refers to the theory that adverse maternal environments influence fetal development and the risk of cardiovascular disease (CVD) in adulthood. To test the hypothesis that ...
Cardiac hypertrophy and expression of the natriuretic peptide system in genetic models of heme oxygenase-1
Objective: Heme oxygenase-1 (HO-1) has been well established as a cytoprotective molecule, and has been shown to exert cardioprotective effects in both hypertension and cardiac hypertrophy. However, the precise mechanism ...