Now showing items 1-5 of 5
Functional analysis of single nucleotide polymorphisms in the proximal promoter regions of the multidrug transporter genes MRP1/ABCC1 and MRP4/ABCC4
The ATP-binding cassette (ABC) transporter superfamily consists of 49 members, to which both Multidrug Resistance Protein 1 (MRP1/gene symbol: ABCC1) and MRP4 (ABCC4) belong. Single nucleotide polymorphisms (SNPs) in drug ...
Characterizing ErbB2-induced mammary tumourigenesis
Approximately 30% of human breast cancers demonstrate overexpression of the receptor tyrosine kinase ErbB2/HER2/Neu, with these cases correlating with recurrence and poor prognosis. While therapy targeting ErbB2 has met ...
Cloning and Functional Characterization of the Retinoic Acid-Catabolizing Enzyme CYP26B1 in Mouse Development
Retinoic acid (RA) is an active metabolite of vitamin A that is essential for embryonic development, and homeostasis of adult tissues. RA is a ligand for the nuclear retinoic acid receptor, and RA-mediated signaling is ...
Functional consequences of the direct physical interaction between E2A transcription factors and CBP/p300
The E2A locus is involved in chromosomal translocations associated with acute lymphoblastic leukemia. The most common of these involves a translocation between chromosomes 1 and 19 (t1;19), resulting in expression of the ...
PROTEIN KINASE A, EXCHANGE PROTEIN ACTIVATED BY cAMP 1, AND PHOSPHODIESTERASE 4D ALL ASSOCIATE WITH VE-CADHERIN TO REGULATE ENDOTHELIAL BARRIER FUNCTION
Vascular endothelial cells (VECs) play an essential role in regulating the passage of macromolecules and cells between the blood stream and underlying tissues. The second messenger 3’, 5’ cyclic adenosine monophosphate ...