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Chalcogenopyrylium Dyes as Modulators of Multidrug Resistance Protein (MRP) 1, MRP2 and MRP4 Transport Activities
MRPs mediate the ATP-dependent efflux of a structurally diverse array of compounds. Certain MRPs, including MRP1, MRP2 and MRP4, are involved in multidrug resistance in tumour cells, while in non-malignant cells these MRPs ...
INTEGRATING PHOSPHOLIPID AND CYCLIC NUCLEOTIDE SIGNALING: ROLES OF PHOSPHODIESTERASES AS ENZYMES AND TETHERS
Cells of the cardiovascular system translate incoming extracellular signals from hormones and drugs through binding of cell surface receptors, and activation of intracellular signaling cascades allowing modulation of ...
The Role of Cadherin-11 and gp130 in Transformation by Activated Src
Signal Transducer and Activator of Transcription 3, Stat3, has been associated with cytokine-induced proliferation, anti-apoptosis and neoplastic transformation, while constitutively active Stat3 has been found in many ...
Itch E3 ubiquitin ligase regulates LATS1 tumour suppressor stability
The Large Tumor Suppressor 1 (LATS1) is a serine/threonine kinase and tumor suppressor found down-regulated in a broad spectrum of human cancers. It is a central player of the emerging Hippo-LATS tumour suppressor pathway, ...
Understanding the Hippo-LATS pathway in tumorigenesis
The Hippo-LATS signaling pathway originally identified in Drosophila is conserved in mammalian systems and serves essential roles in mediating size control as well as tumorigenesis. In humans, the core kinase cassette ...
RET Mediated Gene Expression and Cell-Migration
The RET receptor tyrosine kinase is important during development of neural crest-derived tissues, particularly the enteric and sympathetic nervous systems, and in kidney morphogenesis. Activation of RET requires complex ...