Now showing items 1-5 of 5
The effect of biomechanical and biochemical regulators on the expression of Factor VIII and von Willebrand Factor in endothelial cells
The coagulant protein Factor VIII (FVIII) has been the subject of much debate and controversy regarding where, when, and how it is expressed and produced in the human body for much of the past 30-40 years. Expression was ...
Investigating the Role of cAMP-Signaling in the Regulation of Vascular Endothelial Cell Adaptive Responses to Fluid Shear Stress
The circulating blood exerts a force on the vascular endothelium, termed fluid shear stress (FSS), which directly impacts numerous vascular endothelial cell (VEC) functions. For example, high rates of linear and undisturbed ...
Characterization of ALDH1A1 as a novel tumorigenic target mediating TAZ-induced lung tumorigenesis and stem cell phenotypes
Recent studies suggest that lung cancer stem cells (CSCs) may play major roles in lung cancer development, metastasis and drug resistance. Therefore, identification of lung CSC drivers may provide promising targets for ...
Kinome-wide CRISPR-Cas9 screen to identify kinases involved in Taxol resistance in breast cancer
Breast cancer is the most frequently diagnosed cancer in women, accounting for over 25% of cancer diagnoses and 13% of cancer-related deaths in Canadian women. There are many types of therapies for treatment or management ...
EVALUATION OF THE AGE-RELATED PATHOPHYSIOLOGY OF VON WILLEBRAND FACTOR
von Willebrand Factor (VWF) is a plasma multimeric glycoprotein involved in platelet adhesion and aggregation at sites of vascular injury, and the carrier for coagulation Factor VIII (FVIII). Levels of VWF are influenced ...