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Molecular Stress Signaling in Breast Epithelial Cells
ABSTRACT Breast cancer is a complex disease, whose etiology is not well understood. A number of factors have been found to contribute to its development. Psychological stress has been recognized as such a factor in ...
Validation of a Gene-Expression Based Assay for BRCA1 Function
Breast cancer is a disease that afflicts a significant proportion of women globally. 5-10% of breast cancer cases are linked to inherited polymorphisms in critical genes such as BRCA1, a tumour suppressor essential for ...
THE NRF-1/GABP/BRCA1 Transcriptional Network in Mammary Epithelial Differentiation
Evidence indicates that the mammary epithelium is arranged in a hierarchy in which mature luminal and myoepithelial cells are derived from stem cells through a series of lineage-restricted intermediates. One of the more ...
The Identification of BRCA1 and BRCA2 Mutation Carriers Using Functional Genomic Assays
An estimated 5-10% of breast cancers are hereditary in nature and are due to the presence of a mutation in a breast cancer predisposition gene; approximately half of these cases possess a mutation in BRCA1 or BRCA2. Many ...
DEVELOPMENT OF A FUNCTIONAL ASSAY FOR DETERMINATION OF BRCA1 CARRIER STATUS
Given the high risk of cancer development associated with BRCA1 mutation carriers, it is important that they be identified early and accurately. Identification is impeded however, by the large number of variants of unknown ...