Now showing items 1-5 of 5
Characterization of isoform specific RET knockdown in cancer cell lines
The REarranged in Transfection (RET) tyrosine kinase is an important signalling protein for the development of neural crest-derived tissues such as the enteric and sympathetic nervous systems. RET is constitutively activated ...
Identification and characterization of ΔNp63 as a novel transcriptional target negatively regulated by TAZ in mammary tumorigenesis
The transcriptional co-activator with PDZ-binding domain (TAZ) is a key downstream component of the Hippo pathway that plays important roles in animal size control, stem cell renewal, differentiation and tumorigenesis. We ...
RET Mediated Gene Expression and Cell-Migration
The RET receptor tyrosine kinase is important during development of neural crest-derived tissues, particularly the enteric and sympathetic nervous systems, and in kidney morphogenesis. Activation of RET requires complex ...
APPLICATION OF CYSTEINE SCANNING MUTAGENESIS TO THE MULTIDRUG RESISTANCE PROTEIN (MRP)1
Multidrug resistance protein (MRP)1, a member of the ABCC branch of the ATP-binding cassette (ABC) superfamily of transporters, can confer resistance to a broad spectrum of chemotherapeutic agents. In addition to the core ...
A Role for Fer in Prostate and Breast Cancer
Phosphorylation of substrates by kinase proteins is one of the most prominent mechanisms by which signal transduction occurs and dysregulation of this activity is implicated as a major underlying cause of a number of ...