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Characterization of isoform specific RET knockdown in cancer cell lines
(2013-08-30)
The REarranged in Transfection (RET) tyrosine kinase is an important signalling protein for the development of neural crest-derived tissues such as the enteric and sympathetic nervous systems. RET is constitutively activated ...
Investigating the relationship between the RET receptor, Cbl and ARHGEF7 in downregulation of RET
(2008-07-15)
The RET proto-oncogene encodes a receptor tyrosine kinase (RTK), with two major isoforms, RET9 and RET51, which differ in their C-termini, and therefore recruit different signaling complexes. RET plays an important role ...
RET receptor activation targets expression of the pleiotropic cytokine interleukin-11
(2015-01-20)
The RET receptor has diverse roles in development and disease, modulating proliferation, survival, and migration of cells. Ligand-independent constitutively active forms of RET can lead to thyroid neoplasia. Missense ...
The RET receptor tyrosine kinase: mechanism, signaling and therapeutics
(2010-06-07)
The RET receptor tyrosine kinase has essential roles in cell survival, differentiation, and proliferation. Oncogenic activation of RET causes the cancer syndrome multiple endocrine neoplasia type 2 (MEN 2), and is a frequent ...
RET Mediated Gene Expression and Cell-Migration
(2011-11-08)
The RET receptor tyrosine kinase is important during development of neural crest-derived tissues, particularly the enteric and sympathetic nervous systems, and in kidney morphogenesis. Activation of RET requires complex ...
The Role of BetaPIX in RET-mediated Cell Migration
(2009-09-23)
RET is a transmembrane receptor that is implicated in a variety of processes such as cell proliferation, differentiation, migration, survival, and death. One of the proteins that is activated downstream of RET is the guanine ...
Subcellular localization and trafficking of the RET receptor tyrosine kinase: implications for signalling and disease
(2012-09-18)
The RET proto-oncogene encodes a receptor tyrosine kinase (RTK) that is widely expressed in neuroendocrine tissues and is essential for embryonic development of the kidney and enteric nervous system. Mutations leading to ...