Now showing items 1-5 of 5
The molecular mechanism of TAZ-induced mammary tumorigenesis
TAZ (Transcriptional co-activator with PDZ-binding motif) is a WW-domain containing protein recently identified as a downstream component of the Hippo tumor suppressor pathway and mediator of biologically important processes ...
Exploring the regulation of YAP and TAZ in antitubulin drug response and mammary tumorigenesis
TAZ and YAP are transcriptional coactivators negatively regulated in the tumor suppressor (TS) Hippo pathway. TAZ and YAP play essential roles in tumorigenesis, epithelial mesenchymal transition (EMT) as well as cell ...
Identification and characterization of ΔNp63 as a novel transcriptional target negatively regulated by TAZ in mammary tumorigenesis
The transcriptional co-activator with PDZ-binding domain (TAZ) is a key downstream component of the Hippo pathway that plays important roles in animal size control, stem cell renewal, differentiation and tumorigenesis. We ...
IDENTIFYING THE MOLECULAR MECHANISM OF TAZ-INDUCED LUNG TUMORIGENESIS
The transcriptional co-activator with PDZ-binding domain (TAZ) is a transcriptional co-activator and downstream component of the tumor suppressor Hippo pathway that plays critical roles in organ size control, stem cell ...
Characterization of ALDH1A1 as a novel tumorigenic target mediating TAZ-induced lung tumorigenesis and stem cell phenotypes
Recent studies suggest that lung cancer stem cells (CSCs) may play major roles in lung cancer development, metastasis and drug resistance. Therefore, identification of lung CSC drivers may provide promising targets for ...