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Molecular Stress Signaling in Breast Epithelial Cells
ABSTRACT Breast cancer is a complex disease, whose etiology is not well understood. A number of factors have been found to contribute to its development. Psychological stress has been recognized as such a factor in ...
THE MAMMARY EPITHELIAL CELL-SPECIFIC ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ IN DMBA-MEDIATED BREAST TUMOURIGENESIS
Breast cancer is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths, among women world-wide. Improved understanding of breast tumourigenesis may facilitate the development of more ...
Kinome-wide CRISPR-Cas9 screen to identify kinases involved in Taxol resistance in breast cancer
Breast cancer is the most frequently diagnosed cancer in women, accounting for over 25% of cancer diagnoses and 13% of cancer-related deaths in Canadian women. There are many types of therapies for treatment or management ...
The Role of ALDH1A3 in Normal and Transformed Mammary Gland Development
Aldehyde dehydrogenases (ALDHs) have been used as stem cell markers in a variety of tissues, including the breast. However, it is currently unknown whether ALDH family members participate in normal mammary development or ...
The role of the Fer protein-tyrosine kinase in HER2-positive breast cancer
Fer is a member of a distinct subclass of cytoplasmic protein-tyrosine kinases with homology to a family of adaptor proteins that regulate membrane-cytoskeletal remodeling events, including receptor endocytosis. Fer has ...
The Mammary Epithelial Contribution Of PPARγ In Breast Tumourigenesis
Previous studies with peroxisome proliferator-activated receptor (PPAR)γ heterozygous mice suggest PPARγ normally suppresses 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast tumour progression, but the mechanisms and ...