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The Influence of Sequence Variation on von Willebrand Factor Biosynthesis, Proteolytic Processing and Clearance
Von Willebrand factor (VWF) promotes platelet adhesion and aggregation at sites of vascular damage. This function is directly related to the multimer size of VWF. The VWF-specific metalloprotease ADAMTS13 decreases VWF ...
EVALUATION OF THE AGE-RELATED PATHOPHYSIOLOGY OF VON WILLEBRAND FACTOR
von Willebrand Factor (VWF) is a plasma multimeric glycoprotein involved in platelet adhesion and aggregation at sites of vascular injury, and the carrier for coagulation Factor VIII (FVIII). Levels of VWF are influenced ...
The effect of biomechanical and biochemical regulators on the expression of Factor VIII and von Willebrand Factor in endothelial cells
The coagulant protein Factor VIII (FVIII) has been the subject of much debate and controversy regarding where, when, and how it is expressed and produced in the human body for much of the past 30-40 years. Expression was ...
Aberrant and Alternative Splicing of von Willebrand Factor
von Willebrand disease (VWD) is the most commonly inherited bleeding disorder in humans resulting from quantitative deficiencies or qualitative defects of von Willebrand factor (VWF). VWD can be caused by a variety of ...
The Thrombogenic Influences of Factor VIII and von Willebrand Factor
von Willebrand factor (VWF) and factor VIII (FVIII) circulate in the blood as a non-covalent complex. VWF plays an important role in primary hemostasis through its interactions with components of the extracellular matrix ...