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Sample Size Planning For Detecting Treatment Effect On Biomarker Subset
A vast amount of research has been done on treatment and biomarker interactions, with the hope to recognize a subset of patients that will respond better to new treatments. In particular, Jiang et al. (2007) were interested ...
Statistical Methods For Biomarker Threshold Models in Clinical Trials
In clinical trials, the main objective is to investigate the treatment effects on patients. However, many molecularly targeted drugs or treatments tend to benefit a subset of patients more, identified by a certain biomarker. ...