http://hdl.handle.net/1974/196 2013-06-20T09:51:58Z 2013-06-20T09:51:58Z Dobek, CHRISTINE ELIZABETH http://hdl.handle.net/1974/8083 2013-06-19T05:03:15Z 2013-06-18T04:00:00Z

Title: EFFECTS OF MUSIC ON THE PAIN RESPONSE IN THE CENTRAL NERVOUS SYSTEM USING FUNCTIONAL MAGNETIC RESONANCE IMAGING Authors: Dobek, CHRISTINE ELIZABETH Abstract: The oldest procedure for pain relief has been music. There is abundant behavioural evidence to support music’s pain relieving properties, however, studies to date have yet to investigate music-induced analgesia via imaging. Our first imaging study used thermal stimulation just below pain threshold in combination with various music stimuli, to determine whether music can affect neural activity in response to heat stimuli within brainstem and spinal cord regions. Differential responses to music stimuli were found within regions known for descending modulation, and familiar classical music had a unique effect on neural activity in these regions compared to unpleasant music, reverse music, and no music. This study confirmed that the emotional valence of music affects neural activity in the brainstem and spinal cord. The second study used a well-defined pain paradigm applied with or without favorite music to study the neural activity responses in the brain, brainstem, and spinal cord using imaging. Subjective pain ratings were significantly lower when painful stimuli were administered with music than without music. The pain condition alone elicited neural activity in brain regions consistently activated during similar pain studies. Brain regions associated with pleasurable music listening were activated including limbic, frontal, and auditory regions when comparing music to non-music pain conditions. In addition, neural regions showed activity responses indicative of descending modulation when contrasting the two conditions. These regions include the spinothalamic tract, dorsolateral prefrontal cortex (DLPFC), periaqueductal grey (PAG), rostral ventromedial medulla (RVM), and the dorsal gray matter of the spinal cord. The data suggest that music seems to engage mesolimbic and mesocortical brain regions to activate the descending pain modulation pathway. Lower subjective pain ratings corresponded to a greater suppression in the dorsal gray matter when listening to music. This is the first imaging study to characterize the neural response of pain and how it is mitigated by music listening, and brain and spinal fMRI are appropriate means to study pain processing and its modulation in the central nervous system. Description: Thesis (Master, Neuroscience Studies) -- Queen's University, 2013-06-18 11:33:32.818

2013-06-18T04:00:00Z Tracy, DALE http://hdl.handle.net/1974/8082 2013-06-19T05:05:48Z 2013-06-18T04:00:00Z

Title: Compassion and its Contiguities: Witness Poetry and Metonymic Reponse Authors: Tracy, DALE Abstract: I read witness poetry as a model of response to suffering. Compassion is feeling together with another. Compassion is, then, opposed to empathy’s feeling as another. Compassion can be better understood through the witness poetry that privileges metonymical relationships in which readers are contiguously positioned in relationship to a speaker. This emphasis on relationship can be contrasted to the collapse of relationship in identification in which a reader reads as though he or she is the lyric I, the poetic voice, rather than a listener. I discuss this reader-as-listener in contrast to the trauma studies-influenced discourse surrounding witness poetry, a discourse which focuses on indexical poetic evidence of a poet’s wounds and the transferability of the poet’s trauma to readers. Compassionate response, as demonstrated by this poetry, is premised on a recognition of one’s intimacy with or distance from that which one witnesses. Distance is not synonymous with disengagement, but rather with the space of relationship through which connection and consideration is possible. All intimacy involves some distance; the two are not opposites, but a continuum. Witness involves waiting: response derives from the time of relation through which it might form. This waiting has reflection as its retrospective partner. Together, they form commemoration, which brings reflection into future and communal celebration and remembrance. Com-memoration is linked to com-passion in this communal element. My project engages witness poetry as a communal form inviting feeling in community, response to widespread suffering, and the establishment of relationship and connection. Description: Thesis (Ph.D, English) -- Queen's University, 2013-06-18 10:21:39.793

2013-06-18T04:00:00Z ABD. RAHMAN AZMI, ALYZA AZZURA http://hdl.handle.net/1974/8081 2013-06-19T05:05:38Z 2013-06-18T04:00:00Z

Title: HYDROXYPHENOL INTERACTIONS WITH IRON AND ALUMINUM OXIDE COLLOIDS BY CHEMICAL FORCE SPECTROMETRY Authors: ABD. RAHMAN AZMI, ALYZA AZZURA Abstract: Tannins and humic substances commonly referred to as natural organic matter (NOM), constitute an important component of natural water and soil systems. These species contain numerous phenol and carboxyl functional groups whose reactivity is strongly dependent on both the quantity and location of these moieties on the aromatic ring. In the realistic environmental conditions, both phenolic and carboxylic functional groups are adsorbed on a variety of colloidal metal oxide surfaces. Unfortunately, due to the complexity of humic-based substances, experimental data involving mineral-humate interactions are difficult to interpret. Here, we aim to develop a more detailed understanding of mineral-NOM interactions in aquatic systems, using self-assembled monolayers (SAMs) of simple organic acids having functional groups similar to those found in humic substances. SAMs of 4-(12-mercaptododecyl)benzene-1,2-diol (o-hydroxyphenol-terminated), 5-(12-mercaptododecyl)benzene-1,3-diol (m-hydroxyphenol-terminated), bis(11-thioundecyl) hydrogen phosphate (monoprotic phosphate) and 11-thioundecyl dihydrogen phosphate (diprotic phosphate) were prepared and deposited on a Au(111) surface. The composition of elements present on the surface were determined by X-ray Photoelectron Spectroscopy (XPS) and the orientation of monolayers on the Au(111) surface was explored by Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) Chemical force spectrometry has been used to determine the surface pKa of the monolayers and further used to explore the role of phenolic groups in the surface complexation of NOM by monitoring adhesion forces between iron and aluminum oxide sample and hydroxyphenol-terminated Atomic Force Microscopy (AFM) modified tip. The results are discussed in the context of hydrogen bonding between corresponding species. The system in which there are multiple hydroxyl groups ortho to the carboxylic groups or adjacent to one another on the benzene ring results in significantly different force-distance profiles when interacting with the hydroxyphenol tip. Description: Thesis (Ph.D, Chemistry) -- Queen's University, 2013-06-18 00:22:06.646

2013-06-18T04:00:00Z Jokela, ANNELI MARIE http://hdl.handle.net/1974/8080 2013-06-18T05:03:29Z 2013-06-17T04:00:00Z

Title: Factors mediating the distribution and impact of the non-native invertebrate predator Bythotrephes longimanus Authors: Jokela, ANNELI MARIE Abstract: Predicting the impacts of non-native species remains one of the greatest challenges to invasion ecologists. Because of their insularity, freshwater systems are particularly vulnerable to invasions, especially from non-native predators. The research in this thesis explores the role of abiotic and biotic factors in mediating the distribution and impact of Bythotrephes longimanus, a predatory cladoceran that has been introduced to freshwater systems in North America. Although the general impacts of this invasion have been documented, little is known about the factors that modulate them. Using a combination of field surveys and experiments, I tested several hypotheses concerning the influence of interactions with native species, as well as the role of heterogeneity in the light environment, in mediating the impact of Bythotrephes. Results demonstrated that biotic resistance by native macroinvertebrate predators does not play a limiting role in the establishment success of Bythotrephes. However, the within-lake distribution of Bythotrephes was influenced by these macroinvertebrates, suggesting that the native predator context matters when trying to understand the impacts of non-native predators. This was demonstrated with a mesocosm experiment in which the impact of Bythotrephes was constrained by the native Chaoborus larvae. In terms of the abiotic environment, in situ feeding experiments demonstrated that refuges from impact could exist for some prey taxa, as the outcome of predation by Bythotrephes was dependent on light availability and some prey taxa were more successful at evading predation under low light conditions. Finally, results show that adaptive behaviour by prey is also an important determinant of impact, as migrating Daphnia can escape predation effects by Bythotrephes. The combination of light-limited predation and a shallow distribution by Bythotrephes selects for prey that occupy relatively deeper positions during the day. As a whole, this research highlights the importance of complex interactions in mediating the impact of Bythotrephes and may help to explain some of the variation that has been documented among invaded lakes. A better understanding of these complex interactions can improve our ability to anticipate impacts as Bythotrephes continues to spread, as well as provide insight on some of the long-term effects following invasion. Description: Thesis (Ph.D, Biology) -- Queen's University, 2013-06-17 09:26:35.221

2013-06-17T04:00:00Z