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Please use this identifier to cite or link to this item: http://hdl.handle.net/1974/5141

Title: SYNTHESIS OF BIPYRIDINE-DERIVED LIGANDS FOR DNA BINDING AND SHAPE SWITCHING
Authors: LI, XUE

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Keywords: DNA bending
Pyrene
2, 2'-bipyridine
Issue Date: 2009
Series/Report no.: Canadian theses
Abstract: The objective of this project is synthesizing bipyridine-derived ligands in order to study DNA conformational bending. The synthesis of bipyridine derivatives has been investigated. 6,6’-Dibromo-2,2’- bipyridine and small scale of 6,6’-diformyl-2,2’-bipyridine have been successfully synthesized in the laboratory. The synthesis of large amount of a direct precursor to 6,6’-diformyl-2,2’- bipyridine in an multiple step way has been achieved. The synthesis of mono functionalized pyrene derivatives and of 1,6-dissymmetrically functionalized pyrene derivatives has been heavily studied. Successfully methods have been reported in this thesis. The complete assembly of bipyridine and pyrene units into the final ligands and their model has also been studied. Palladium borylation and Suzuki-Miyaura cross-coupling have been used to successfully connect the bipyridine with pyrene units. In addition to Suzuki-Miyaura methodology, the direct coupling of N,N’-dioxide-2,2’- bipyridine with aromatic bromides under palladium catalysis has been investigated. This method could be an alternative way to access to mono-substituted 6-bipyridines, symmetrically or even asymmetrically 6,6’-disubstituted-2,2’-bipyridine derivatives.
Description: Thesis (Master, Chemistry) -- Queen's University, 2009-09-06 01:06:41.646
URI: http://hdl.handle.net/1974/5141
Appears in Collections:Queen's Theses & Dissertations
Chemistry Graduate Theses

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