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    Optimizing fracture management: Correlating the physical and mechanical properties of bone to computed tomography to generate an estimate of bone quality

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    Date
    2008-02-05
    Author
    Crookshank, Meghan Cathleen Maria
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    Abstract
    Non-invasive estimates of bone quality are of great interest as they could potentially improve the diagnosis and treatments for bone disorders, such as osteoporosis, and could aid in preoperative planning of surgical interventions, improving patient outcomes in orthopaedic trauma.

    Quantitative computed tomography (QCT) is currently being investigated as a method of estimating structural bone mineral content (sBMC) and, thus, bone quality. However, the reported correlations between QCT and sBMC have been variable and the relationships reported between sBMC and the apparent elastic modulus (E*) of bone have been even more variable.

    A series of investigations are presented, relating QCT, sBMC, apparent density and the E* of bone. These studies were performed with the ultimate objective of determining the appropriateness of QCT as a predictor of the E* of bone and whether the E* of bone could be predicted from information regarding the sBMC and apparent density.
    URI for this record
    http://hdl.handle.net/1974/1022
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    • Department of Mechanical and Materials Engineering Graduate Theses
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