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dc.contributor.authorLo, Samanthaen
dc.date2014-09-22 17:39:10.198
dc.date.accessioned2014-09-23T15:39:53Z
dc.date.issued2014-09-23
dc.identifier.urihttp://hdl.handle.net/1974/12478
dc.descriptionThesis (Master, Biology) -- Queen's University, 2014-09-22 17:39:10.198en
dc.description.abstractThe C. elegans nervous system offers a rewarding model in which many pathways can be studied with. There are many genes conserved in both invertebrates and vertebrates that are necessary for proper nervous system development. Of the pathways that affect axon guidance, I focus on the VAB-1/Eph RTK signaling pathway as well as the DAF-2/insulin receptor’s pathway. I show that PTP-3/LAR RPTP can negatively regulate VAB-1/Eph RTK through dephosphorylation in vitro and in vivo and may have VAB-1 independent roles. Additionally, I investigate ptp-3’s relationships with genes involved in both vab-1 and daf-2’s pathways including daf-18/PTEN, unc-34/Enabled, and sax-3/Robo as observed in the C. elegans mechanosensory axons. With loss-of-function and gain-of-function mutants, I demonstrate daf-2’s role for proper axon guidance and the possibility of daf-2 and vab-1 working together as co-receptors in this process. Finally, I replicate results in the AIY interneurons thus suggesting the AIY interneurons to be a potential model in which to study genetic interactions.en
dc.language.isoengen
dc.relation.ispartofseriesCanadian thesesen
dc.rightsThis publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.en
dc.subjectc. elegans nervous system RPTPen
dc.subjectbiology geneticsen
dc.titleIn vivo Interactions between PTP-3 RPTP and Various Signaling Pathways in the Caenorhabditis elegans Nervous Systemen
dc.typethesisen
dc.description.restricted-thesisPotential publication.en
dc.description.degreeM.Sc.en
dc.contributor.supervisorChin-Sang, Ian D.en
dc.contributor.departmentBiologyen
dc.embargo.terms1825en
dc.embargo.liftdate2019-09-22
dc.degree.grantorQueen's University at Kingstonen


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