Browsing Biomedical and Molecular Sciences, Department of by Publish Date
Now showing items 1-20 of 455
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The Relationship between Hospital Infection Surveillance and Control Activities and Antibiotic Resistant Pathogen Rates
(2005-01-13)Objective: The purpose of the study was to examine the relationship of surveillance and control activities in Canadian hospitals with rates of nosocomial methicillin-resistant S. aureus (MRSA), C. difficile associated ... -
Forsdyke's Webpages
(2005-02-15) -
Structural determination and functional annotation of ChuS and ChuX, two members of the heme utilization operon in pathogenic Escherichia coli O157:H7
(2007-07-05)For pathogenic microorganisms, heme uptake and degradation is a critical mechanism for iron acquisition that enables multiplication and survival within hosts they invade. While the bacterial proteins involved in heme ... -
An evaluation of the efficiency of lymphocytic choriomeningitis virus - nucleoprotein cross priming in vivo
(2007-07-11)During viral infections, CD8+ T cells only respond to a select few epitopes derived from the respective foreign pathogen. These epitopes can be organized into a hierarchy, based on their ability to induce T cell priming. ... -
Identification and characterization of N-glycosylation and structural genes involved in flagellation of methanogenic archaea from the genus Methanococcus
(2007-07-19)The archaeal flagellum is a unique motility structure. Although functionally similar to the bacterial flagellum, the archaeal flagellum shares more similarities to the bacterial type IV pilus. Using the methanogenic archaea ... -
Prolonged dietary iron restriction alters total tissue iron but not heme iron: lack of impact on blood pressure and salt sensitivity
(2007-08-02)The World Health Organization (WHO) states that iron deficiency (ID) is the preeminent global micronutrient deficiency. Maternal ID is linked to cardiovascular disease and hypertension in offspring, and yet the impact of ... -
Influence of Membrane-Damaging Agents and the Sigma Factor AlgU on the Induction of the MexCD-OprJ Efflux System of Pseudomonas Aeruginosa
(2007-08-02)The MexCD-OprJ multidrug efflux pump of Pseudomonas aeruginosa confers resistance to a range of antimicrobials. Although not expressed under normal laboratory conditions, exposure to the membrane-active biocides, chlorhexidine ... -
Regulation of inflammation by the Fps/Fes protein tyrosine kinase
(2007-09-17)Fps/Fes and Fer are members of a distinct subfamily of cytoplasmic protein tyrosine kinases that have recently been implicated in the regulation of innate immunity. Previous studies showed that mice lacking Fps/Fes are ... -
The Influence of Copper Binding on the Stability of the SCO Protein from Bacillus subtilis
(2007-09-25)Every aerobic organism expresses cytochrome c oxidase to catalyze reduction of molecular oxygen to water, and takes advantage of this energy releasing reaction to produce an electrochemical gradient used in cellular energy ... -
PA3719-Mediated Regulation of the MexAB-OprM Efflux System of Pseudomonas aeruginosa
(2007-09-26)Intrinsic antimicrobial resistance of the opportunistic human pathogen Pseudomonas aeruginosa has mainly been attributed to the presence of several chromosomally-encoded multidrug efflux systems. The MexAB-OprM system ... -
NMR and Biophysical Studies of Modular Protein Structure and Function
(2007-09-28)Proteins modularity enhances the multi-functionality and versatility of proteins by providing such properties as multiple and various ligand-binding sites, increased ligand affinity through the avidity effect, and the ... -
Analysis of N-linked glycosylation of flagellin proteins in the archaeon Methanococcus maripaludis
(2007-10-01)N-linked glycosylation is a posttranslational modification involving the attachment of a carbohydrate to an asparagine (Asn) residue located within an Asn-X-Ser/Thr consensus sequence. This process is well understood in ... -
Up-regulation of HO-1 attenuates left ventricular remodeling post myocardial infarction in rats
(2007-10-03)Background/Objective: Reperfusion injury is a serious consequence of blood flow reestablishment after myocardial infarction (MI) mediated by reactive oxygen species and neutrophilic cellular damage. Following MI, the left ... -
A novel TAFIa assay and its use to measure TAFI activation in vivo in primate models and the determination of the kinetics of TAFIa-catalyzed release of bound plasminogen from soluble fibrin degradation products
(2007-10-11)Thrombin-activatable fibrinolysis inhibitor (TAFI), also called procarboxypeptidase U (proCPU), is a plasma zymogen that can be activated by thrombin, the thrombin-thrombomodulin complex, or plasmin. The activated form ... -
Archaeal signal peptides and cell surface structures
(2007-10-11)Archaeal protein trafficking is a poorly understood process that is only beginning to unfold. Integral to this process are the various signal peptidases. Two types of archaeal signal peptidases are identified thus far: ... -
Transient Lipopolysaccharide-Induced Cytokine Responses in the Maternal and Fetal Guinea Pig
(2007-11-29)The aim of this study was to further investigate the role of pro-inflammatory cytokines in the pathogenesis of fetal cererbral white matter injury associated with chorioamnionitis by charaterizing the time course of the ... -
Analysis of a bacterial serine/threonine kinase
(2007-12-05)RdoA is a bacterial protein kinase from Salmonella enterica serovar Typhimurium first noted for its regulation of dsbA expression in this organism. The crystal structure of RdoA’s homologue, YihE from Escherichia coli, ... -
Proteomic analysis of heart failure : insights into myofibril assembly and regulation
(2008-01-09)Heart failure (HF) is a prevalent disease in society which is associated with decreased cardiac output. This thesis describes the proteomic analysis of cardiac tissue obtained from HF patients and a transgenic animal model ... -
The effects of 1,4-benzoquinone on c-Myb and topoisomerase II in K-562 cells
(2008-01-11)Exposure to benzene, a ubiquitous environmental pollutant, has been linked to leukemogenesis, although the mechanism of benzene initiated carcinogenesis remains unclear. It has been proposed that benzene can be bioactivated ...