Browsing Biomedical and Molecular Sciences, Department of by Subject "4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone"
Now showing items 1-3 of 3
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Biotransformation and DNA Repair in 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Pulmonary Carcinogenesis
(2008-11-17)Studies described in this thesis were at aimed at characterizing the mechanisms involved in the pulmonary carcinogenicity of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), by ... -
DNA oxidation and base excision repair in lung and liver of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone treated mice
(2011-04-29)4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent pulmonary carcinogen found in unburned tobacco and tobacco smoke. To exert its carcinogenic effect, NNK is metabolically activated to reactive intermediates ... -
Investigation of the Biotransformation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone by Prostaglandin H Synthase and Cytochrome P450 2F
(2008-01-15)The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is believed to play a role in human lung cancer induced by tobacco smoking. NNK biotransformation may involve the enzymes prostaglandin ...