Now showing items 1-10 of 105
The Relationship between Hospital Infection Surveillance and Control Activities and Antibiotic Resistant Pathogen Rates
Objective: The purpose of the study was to examine the relationship of surveillance and control activities in Canadian hospitals with rates of nosocomial methicillin-resistant S. aureus (MRSA), C. difficile associated ...
Studies of Coagulation and Fibrinolysis
The mechanism and regulation of prothrombinase function in the activation of prothrombin and prethrombin-1 were studied. In addition, the kinetics of plasmin-mediated fibrin degredation were determined. First, the mechanism ...
The Area Postrema: A Potential Site for Circadian Regulation by Prokineticin 2
Little is known regarding the neurophysiological mechanisms by which the neuropeptide prokineticin 2 (PK2) regulates circadian rhythms. Using whole-cell electrophysiology, we have investigated a potential role for regulation ...
Size Matters: The Influence of Isoform Size on the Intracellular Processing of Apolipoprotein(a)
High plasma concentrations of Lipoprotein(a) (Lp(a)) have been identified as a risk factor for a variety of atherogenic disorders such as cerebrovascular disease, peripheral vascular disease, and coronary heart disease. ...
Paradoxical Effects of Immune Cells on the Enteric Nervous System in Intestinal Inflammation
Inflammatory bowel disease causes structural and functional alterations in the enteric nervous system (ENS). Since the onset of intestinal inflammation involves the activation of resident immune cells as well as rapid ...
Investigating the role of reactive oxygen species in transplacental benzene carcinogenesis
The incidence of childhood leukemia is increasing, especially in urbanized areas. It is hypothesised that transplacental exposure to environmental carcinogens, such as benzene, plays a role in the etiology of childhood ...
SFO Neurons are Glucose Responsive
Glucose is the primary metabolic signal reflecting the current energy state of the body. Glucose influences the excitability of neurons in the area postrema (AP), a circumventricular organ (CVO), prompting my interest in ...
The Role of Lipoprotein(a)/Apolipoprotein(a) in Endothelial Dysfunction: Mechanistic Studies in Vascular Endothelium
Multiple lines of evidence suggest that elevated plasma lipoprotein(a) (Lp(a)) concentrations are a significant risk factor for the development of a number of vascular diseases including coronary heart disease and stroke. ...