Now showing items 1-10 of 16
NMR and Biophysical Studies of Modular Protein Structure and Function
Proteins modularity enhances the multi-functionality and versatility of proteins by providing such properties as multiple and various ligand-binding sites, increased ligand affinity through the avidity effect, and the ...
Influence of Membrane-Damaging Agents and the Sigma Factor AlgU on the Induction of the MexCD-OprJ Efflux System of Pseudomonas Aeruginosa
The MexCD-OprJ multidrug efflux pump of Pseudomonas aeruginosa confers resistance to a range of antimicrobials. Although not expressed under normal laboratory conditions, exposure to the membrane-active biocides, chlorhexidine ...
Analysis of N-linked glycosylation of flagellin proteins in the archaeon Methanococcus maripaludis
N-linked glycosylation is a posttranslational modification involving the attachment of a carbohydrate to an asparagine (Asn) residue located within an Asn-X-Ser/Thr consensus sequence. This process is well understood in ...
An evaluation of the efficiency of lymphocytic choriomeningitis virus - nucleoprotein cross priming in vivo
During viral infections, CD8+ T cells only respond to a select few epitopes derived from the respective foreign pathogen. These epitopes can be organized into a hierarchy, based on their ability to induce T cell priming. ...
Analysis of a bacterial serine/threonine kinase
RdoA is a bacterial protein kinase from Salmonella enterica serovar Typhimurium first noted for its regulation of dsbA expression in this organism. The crystal structure of RdoA’s homologue, YihE from Escherichia coli, ...
The Influence of Copper Binding on the Stability of the SCO Protein from Bacillus subtilis
Every aerobic organism expresses cytochrome c oxidase to catalyze reduction of molecular oxygen to water, and takes advantage of this energy releasing reaction to produce an electrochemical gradient used in cellular energy ...
Identification and characterization of N-glycosylation and structural genes involved in flagellation of methanogenic archaea from the genus Methanococcus
The archaeal flagellum is a unique motility structure. Although functionally similar to the bacterial flagellum, the archaeal flagellum shares more similarities to the bacterial type IV pilus. Using the methanogenic archaea ...
PA3719-Mediated Regulation of the MexAB-OprM Efflux System of Pseudomonas aeruginosa
Intrinsic antimicrobial resistance of the opportunistic human pathogen Pseudomonas aeruginosa has mainly been attributed to the presence of several chromosomally-encoded multidrug efflux systems. The MexAB-OprM system ...
Regulation of inflammation by the Fps/Fes protein tyrosine kinase
Fps/Fes and Fer are members of a distinct subfamily of cytoplasmic protein tyrosine kinases that have recently been implicated in the regulation of innate immunity. Previous studies showed that mice lacking Fps/Fes are ...