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NMR and Biophysical Studies of Modular Protein Structure and Function
Proteins modularity enhances the multi-functionality and versatility of proteins by providing such properties as multiple and various ligand-binding sites, increased ligand affinity through the avidity effect, and the ...
Analysis of Lipoprotein(a) Catabolism
Elevated plasma concentrations of lipoprotein(a) [Lp(a)] have been identified as an independent risk factor for vascular diseases including coronary heart disease and stroke. In the current study, we have examined the ...
Studies of Coagulation and Fibrinolysis
The mechanism and regulation of prothrombinase function in the activation of prothrombin and prethrombin-1 were studied. In addition, the kinetics of plasmin-mediated fibrin degredation were determined. First, the mechanism ...