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A Novel Role for Calpain 4 in Podosome Assembly
Podosomes are adhesive and invasive structures which may play an important role in numerous physiological and pathological conditions including angiogenesis, atherosclerosis, and cancer metastasis. Recently, the cysteine ...
The Calpain Protease Active Site: A Target for Inhibitor and Activity-Based Probe Design
The calpain family of intracellular Ca2+-dependent cysteine proteases is involved in a number of intracellular signaling processes. Calpain hyperactivity has also been implicated in ischemic injury, neurodegenerative ...
Regulatory Domains of the Human Calpain Family
Calpains are intracellular enzymes that merge cysteine protease and calcium sensing activities together in one molecule. They respond to Ca2+ signals and modify the activity of their targets by selective proteolysis. ...
Calpain: Transitioning From the Use of the Protease Core to the Full-Length Enzyme for the Development of Specific Substrates and Inhibitors
Calpains are a family of calcium-dependent cysteine proteases involved in intracellular signaling. They participate in many normal cellular processes such as cell motility and apoptosis but when over-activated they contribute ...