Now showing items 101-105 of 105
Role of Activated Macrophages and Pro-Inflammatory Cytokines in Placental Trophoblast Invasion and Fetal Outcome
The invasion of trophoblast cells into the uterine wall is an essential component of normal human pregnancy. These trophoblast cells transform the uterine spiral arterioles into high-flow, low-resistance vessels that supply ...
Transient Lipopolysaccharide-Induced Cytokine Responses in the Maternal and Fetal Guinea Pig
The aim of this study was to further investigate the role of pro-inflammatory cytokines in the pathogenesis of fetal cererbral white matter injury associated with chorioamnionitis by charaterizing the time course of the ...
Contribution of a Sperm Protein, PAWP, to the Signal Transduct Pathway During Vertebrate Fertilization
PAWP, postacrosomal sheath WW domain binding protein, is a novel sperm protein identified as a candidate sperm borne, oocyte-activating factor (SOAF). PAWP induces both early and later egg activation events including meiotic ...
Investigation of the Biotransformation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone by Prostaglandin H Synthase and Cytochrome P450 2F
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is believed to play a role in human lung cancer induced by tobacco smoking. NNK biotransformation may involve the enzymes prostaglandin ...
Investigating the contribution of the basal ganglia in the selective gating of saccade initiation
An important function of the brain is to inhibit irrelevant behaviors. This thesis examines the role of the basal ganglia in response suppression using saccadic eye movements as a model of behavior. We measured the activity ...