Now showing items 11-14 of 14
Transient Lipopolysaccharide-Induced Cytokine Responses in the Maternal and Fetal Guinea Pig
The aim of this study was to further investigate the role of pro-inflammatory cytokines in the pathogenesis of fetal cererbral white matter injury associated with chorioamnionitis by charaterizing the time course of the ...
IL-27 Enhances LPS-Induced Proinflammatory Responses in Human Monocytes: Augmented Inflammasome Activity and IL-23 Expression
Inflammation plays an important role in responding to injury and combating infections. In this thesis, I examine how inflammation is regulated by cytokines responsible for driving initial immune responses to combat ...
Abnormal inflammation in a rat model of spontaneous fetal loss leads to maternal coagulopathies associated with placental haemostatic alterations
Spontaneous foetal loss is the most common complication of pregnancy, affecting up to 20% of recognized pregnancies and recurring in 1-3% of cases. Abnormal maternal inflammation and systemic maternal coagulopathies are ...
Effects of Increased Inflammation on Antiviral CD8+ T Cell Responses in Mice Overexpressing the Human-Cysteinyl Leukotriene 2 Receptor (hCysLT2R)
Inflammation plays a vital role in promoting naïve cytotoxic T lymphocyte (CD8+ T cell) differentiation. Infection with lymphocytic choriomeningitis virus (LCMV) elicits a robust CD8+ T cell response in the mouse. Cysteinyl ...