Department of Pathology and Molecular Medicine Faculty Publications

The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF-dependent and independent manner

Swystun, Laura L.; Notley, Colleen; Georgescu, Ilinca; Lai, Jesse D.; Nesbitt, Kate; James, Paula D.; Lillicrap, David (2019-02-11)

Essentials CLEC4M is an endocytic receptor for factor FVIII. CLEC4M interacts with FVIII in a VWF-dependent and independent manner. CLEC4M binds to mannose-containing glycans on FVIII. CLEC4M internalization of FVIII ...