Neuroscience Studies (CNS), Centre for
The Centre for Neuroscience Studies is a hub of multidisciplinary research and teaching aimed at improving our understanding of the brain, how it works and how new therapies and diagnoses can play an important role in the prevention and treatment of diseases like Parkinson’s, Alzheimer’s, Stroke, Obesity, Fetal Alcohol Spectrum Disorder, Schizophrenia, Behavioral Disorders, Depression to name a few.
This community includes research outputs produced by faculty and students. Submitting works to QSpace may enable compliance with the Tri-Agency Open Access Policy on Publications.
When you submit your work to QSpace, you retain copyright and grant the Library a non-exclusive license to distribute and preserve. Works are open access unless restricted by the creator.
Collections in this community
Recent Submissions
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Characterizing the Effects of Sub-Concussive Head Impacts on Brain Biomarkers: a Multi-Modal Approach Toward Developing Safer Practices on the Football Field
Growing literature has raised concerns that repeated sub-concussive impacts to the head may induce changes in both structural and functional brain biomarkers. Despite these findings however, evidence from neuroimaging using ... -
RET Activation by Glial Cell Line-Derived Neurotrophic Factor Protects Myenteric Neurons Against Selectively Lethal Challenge by Inflammation
Intestinal functions are predominantly controlled by the enteric nervous system (ENS), which is comprised of the inner submucosal and outer myenteric plexuses. The myenteric plexus innervates the intestinal smooth muscle ... -
Predicted Position Error Triggers Catch-Up Saccades During Sustained Smooth Pursuit
Humans are largely visual animals and require that images of objects of interest must be held steadily on the fovea, a region on the retina that allows for high visual acuity. In order to maintain gaze on objects in the ... -
Investigating the Initiation of Spreading Depolarizations
Ischemic stroke is one of the most prevalent, devastating and therapeutically challenging medical conditions. Following brain ischemia, failure of the Na+/K+ ATPase is linked with a massive cationic influx through an ... -
Formation of a Normative Comparison Base by Physiological Factors, Personality Dimensions and Neural Correlates
Introduction: There is variance in a healthy population, but it is poorly characterized and understood. Variations can come from common factors like demographics, experience of early life stress (ELS), physiological factors ... -
Pharmacological treatment for insomnia in patients with major depressive disorder
(Taylor and Francis, 2019-05-16)Introduction: Insomnia in Major Depressive Disorder (MDD) is highly prevalent and associated with increased suffering and functional impairment. Effective, evidence-based treatments for insomnia in MDD are an unmet need ... -
Poor Regional Cerebral Oxygenation During Critical Illness May Be Associated With Acute and Chronic Neurological Dysfunction
Survivors of critical illness frequently exhibit acute (i.e., delirium) and chronic neurological complications. Intensive care unit prevalence of delirium is as high as 80% and has been associated with increased length of ... -
Neural Processing in Primary Motor Cortex and its Relationship to Contralateral and Ipsilateral Motor Actions
The role of primary motor cortex (M1) in controlling movements has been a long-debated subject because M1 neurons have been shown to relate to many different aspects of motor control. A confounding issue is that different ... -
Confidence intervals and measures of significant change for KINARM Standard Tests
Neurological assessment plays a pivotal role in the overall diagnostic and prognostic process of patient care. The effectiveness of the various examinations and methods of neurological assessment are based on the accuracy ... -
Frequency & Magnitude of Helmet Impacts in One Season of Collegiate Football: An Investigation Into the Effect of Session and Position Type
Background: Concussive and subconcussive head impacts play important roles in long-term brain health. Professional and collegiate football leagues have been taking steps to reduce dangerous and injurious hits during games, ... -
Estrogens in the bed nucleus of the stria terminalis: State-dependent modulation of inhibitory synaptic transmission in rats
Beyond their important role in reproduction, estrogens contribute in various adaptive and maladaptive physiological phenomena including, but not limited to, appetite, stress response, and the development of compulsive ... -
Neuromodulatory and metaplastic regulation of long-term synaptic plasticity in the primary visual cortex of adult rats.
Synaptic plasticity in the neocortex of mammals is influenced by various neuromodulators and metaplasticity mechanisms. These regulatory processes allow synaptic networks to operate and adjust to various behavioral states ... -
Understanding the neurobiological basis of mixed-strategy decision-making in health and disease
During competitive interactions involving multiple agents, such as sporting competitions, the outcome of each individual’s actions is dependent not only on a historical sequence of their own choices, but on those of ... -
EXAMINING THE NEURAL AND COGNITIVE PROCESSES UNDERLYING TYPICAL AND ATYPICAL READING ABILITY
Although reading is an important and generative skill that is important for a child’s future academic, economic, and social success, it remains controversial how it develops and what leads to reading difficulties. Furthermore, ... -
Qualitative evaluation of an anti-stigma intervention to reduce the impact of stigma in individuals with mental illness
Objectives: To evaluate the effectiveness of a group-based, psychoeducational and behavioural modification intervention, Overcoming Stigma in Mood and Anxiety Disorders, in reducing the impact of mental-illness-related ... -
Stress-Related Effects of Phoenixin on Nucleus of the Solitary Tract Neurons
Phoenixin (PNX) is a recently discovered neuropeptide that was initially determined to positively contribute to reproductive functioning. Since its discovery, however, PNX has been implicated in a diverse range of physiological ... -
Change in a person's cognitive/emotional state, including expecting pain, is linked to connectivity change in identified brainstem and spinal cord networks
Resting-state functional MRI examines activity of the central nervous system in the absence of a specific task or stimulus, and has been used to investigate coordinated activity within the cerebral hemispheres, as well as ... -
Neuropsychiatric-like behavioural features of the Aldh2-/- mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is a complex, multifaceted neurodegenerative disorder characterized by progressive memory impairment and frequently presents with neuropsychiatric comorbidities, notably anxiety and depression. We ... -
Neuropeptides in the Bed Nucleus Stria Terminalis: Implications in Chronic Stress
For the last 20-30 years, new discovery of pharmacological treatment for psychiatric disorders has been stagnant despite a pressing need to find alternative therapies for patients that are treatment-resistant to the current ... -
Tumor necrosis factor alpha influences the excitability of subfornical organ neurons and potentiates angiotensin II-induced calcium activity
Cardiovascular disease is a leading cause of mortality worldwide. Progress has been made in diagnosing and treating this condition, however the mechanisms by which it develops have yet to be fully elucidated. Accumulating ...
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