Neuroscience Studies (CNS), Centre for
The Centre for Neuroscience Studies is a hub of multidisciplinary research and teaching aimed at improving our understanding of the brain, how it works and how new therapies and diagnoses can play an important role in the prevention and treatment of diseases like Parkinson’s, Alzheimer’s, Stroke, Obesity, Fetal Alcohol Spectrum Disorder, Schizophrenia, Behavioral Disorders, Depression to name a few.
This community includes research outputs produced by faculty and students. Submitting works to QSpace may enable compliance with the Tri-Agency Open Access Policy on Publications.
When you submit your work to QSpace, you retain copyright and grant the Library a non-exclusive license to distribute and preserve. Works are open access unless restricted by the creator.
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Recent Submissions
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Investigating the association between cortical morphological features and the properties of underlying WM tracts in healthy young adults
Quantitative measures of gray matter (GM) and white matter (WM) can be derived from structural and diffusion Magnetic Resonance Imaging (MRI) to study the cerebral cortex and WM projections. Previous multimodal research ... -
Developing and Employing a Behavioral Platform to Characterize a non-human Primate Model of Alzheimer's Disease
Alzheimer’s disease (AD) is a devastating neurodegenerative disease and with shifting demographics, the number of affected individuals is estimated to increase dramatically. While a great deal of resources has been dedicated ... -
Coding body and world for reaching movements
To reach to visual targets, we need to transform the visual representation into the coordinate system of the moving arm, i.e. coordinate transformations. Varying body postures such as lying or rolling the head leads to ... -
The effects of subconcussive impacts on white matter integrity in the corpus callosum and corticospinal tracts
Over the course of a football season the athletes are subject to a large number of impacts ranging in magnitude. With these impacts failing to cause any clinical signs of concussion, they often get disregarded as non-injurious. ... -
Partial Molecular and Biochemical Characterization of a Sandhoff Mouse Model
Sandhoff Disease (SD) is a rare genetic disorder which results in progressive neurodegeneration. SD is caused by a build-up of GM2 Gangliosides, a lipid which is stored in the lysosome of neurons. It can occur in infantile, ... -
Motor Memories in Manipulation Tasks are Linked to Contact Events Between Objects
Humans have the remarkable ability to learn and perform motor skills, often involving the manipulation of different objects or tools, such as swinging a hammer or a tennis racket. The objects that we manipulate are usually ... -
Neural correlates and effects of increased cognitive load on performance during the n-back task in major depressive disorder
Background: Major depressive disorder (MDD) is a heterogenous disease that includes debilitating cognitive deficits, including working memory (WM). The n-back task used to examine WM as it requires continuous updating and ... -
Preclinical Assessment of Intravenous Gene Therapy for GM2 Gangliosidosis
GM2 Gangliosidoses are a group of severe neurodegenerative lysosomal storage disorders characterized by the inability to catabolize GM2 Gangliosides, leading to a neurotoxic accumulation of the GM2 lipids within the central ... -
Assessment of Memory in the DP(16)1YEY/+ Mouse Model of Down Syndrome
Down syndrome (DS) is a common genetic condition caused by the presence of three copies of chromosome 21 (trisomy 21). DS greatly increases the risk of Alzheimer’s disease (AD), and a large percentage of people with DS ... -
Plasticity of Vagal Afferent Neurons During Gut Microbial Dysbiosis and Inflammation
Increasing evidence has suggested that vagal afferent neurons can mediate gut microbiota induced effects in the brain and immune modulation during gut inflammation. However, the mechanisms behind the alteration in the ... -
Modulation of neurogenesis and apoptosis in the adult enteric nervous system
Gastrointestinal (GI) disorders are often accompanied by a loss of enteric neurons, leading to GI dysfunction. Although a population of enteric neural stem cells (ENSCs) resides within the adult enteric nervous system ... -
A Window to the Mind: Validation of a New Method to Measure Thought Dynamics Using Brain Network Meta-State Transitions
In addition to what people are thinking about, researchers are also increasingly interested in how humans flow continuously from one mental state to the next (i.e., the flights and perches of thought; James, 1890). Can we ... -
The Effects of Variable Levels of p75 Expression on Aberrant Sympathetic Axon Sprouting Into Sensory Ganglia of Mice Overexpressing Levels of NGF Production
Growth and regeneration of nervous tissue in adult mammalian organisms is limited to a few locations in the body, and to special circumstances that induce proliferation. One way that neuronal trophism can be initiated is ... -
The Relationship Between fMRI and Symptoms of Major Depressive Disorder (CAN-BIND12)
Objective: Major depressive disorder (MDD) is a mental health issue which features a breadth of symptoms and variable presentations. Subsequently, the method of diagnosis/treatment is not one with a clear and infallible ... -
Evidence for effects of phoenixin on neurons of the paraventricular nucleus
The paraventricular nucleus (PVN) of the hypothalamus has been implicated in autonomic regulation. Through projections to the pituitary gland, median eminence and hindbrain, the PVN plays a role in stress response and other ... -
Correction of AB Variant GM2 Gangliosidoses Using AAV9 Viral Vector Gene Therapy in a Mouse Model
GM2 Gangliosidoses are a group of neurodegenerative diseases affecting the brain. In humans, these diseases are characterized by rapid neurological deterioration and death before 4-years of age. GM2 gangliosides are normally ... -
Characterizing the Effects of Sub-Concussive Head Impacts on Brain Biomarkers: a Multi-Modal Approach Toward Developing Safer Practices on the Football Field
Growing literature has raised concerns that repeated sub-concussive impacts to the head may induce changes in both structural and functional brain biomarkers. Despite these findings however, evidence from neuroimaging using ... -
RET Activation by Glial Cell Line-Derived Neurotrophic Factor Protects Myenteric Neurons Against Selectively Lethal Challenge by Inflammation
Intestinal functions are predominantly controlled by the enteric nervous system (ENS), which is comprised of the inner submucosal and outer myenteric plexuses. The myenteric plexus innervates the intestinal smooth muscle ... -
Predicted Position Error Triggers Catch-Up Saccades During Sustained Smooth Pursuit
Humans are largely visual animals and require that images of objects of interest must be held steadily on the fovea, a region on the retina that allows for high visual acuity. In order to maintain gaze on objects in the ... -
Investigating the Initiation of Spreading Depolarizations
Ischemic stroke is one of the most prevalent, devastating and therapeutically challenging medical conditions. Following brain ischemia, failure of the Na+/K+ ATPase is linked with a massive cationic influx through an ...
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