Neuroscience Studies (CNS), Centre for
The Centre for Neuroscience Studies is a hub of multidisciplinary research and teaching aimed at improving our understanding of the brain, how it works and how new therapies and diagnoses can play an important role in the prevention and treatment of diseases like Parkinson’s, Alzheimer’s, Stroke, Obesity, Fetal Alcohol Spectrum Disorder, Schizophrenia, Behavioral Disorders, Depression to name a few.
This community includes research outputs produced by faculty and students. Submitting works to QSpace may enable compliance with the Tri-Agency Open Access Policy on Publications.
When you submit your work to QSpace, you retain copyright and grant the Library a non-exclusive license to distribute and preserve. Works are open access unless restricted by the creator.
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Recent Submissions
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Characterizing the association between regional cerebral oxygen saturation and neurological impairment after cardiac surgery
It is well-known that patients undergoing cardiac surgery are at risk of developing acute, fluctuating (i.e. delirium), and/or long-term post-operative neurological complications. Incidence of neurological impairment can ... -
A Refined Spatiotemporal Analysis of Extracellular Waveforms From Neurons Within the Lateral Intraparietal Area of the Macaque Posterior Parietal Cortex
Extracellular spike waveforms recorded from neurons are known to reflect the intracellular process of action potential generation through the activation and inactivation of ion channels. The variability between the shape ... -
Regulation of the intestinal smooth muscle cell phenotype by the antifibrotic drug nintedanib
The phenotype of the intestinal smooth muscle cell (ISMC) is typically contractile and non- proliferative, but this can be modulated to allow for proliferation as a wound repair mechanism. While phenotypic modulation of ... -
Investigating the Clinical Effects and Mechanistic Underpinnings of Probiotics on Major Depressive Disorder
Background: Probiotics have been hypothesized to improve symptoms of Major Depressive Disorder (MDD). Evidence suggests that these outcomes may be driven by probiotics reducing inflammation and regulating neurotransmission ... -
Excitation of colonic afferent nerves by fecal supernatants from gastrointestinal disease patients
Increased excitability of extrinsic afferent nerves has emerged as an important mechanism of visceral pain during inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). While host-derived mediators have been ... -
Characterizing Neurodegenerative Disease Biomarkers in Cerebrospinal Fluid of Non-human Primates
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by several pathological changes including amyloid plaques, neurofibrillary tangles, synaptic loss, and neuroinflammation. There are currently no disease ... -
Investigation of the processing of proprioception and vision for motor actions at the behavioural and neural levels
Moving in a complex and dynamic environment requires continuous processing of different sources of information. Optimal feedback control (OFC) is a theory of motor control that predicts how information updated by sensory ... -
THE QUANTIFICATION OF NEUROCOGNITIVE IMPAIRMENT ACROSS THE SPECTRUM OF KIDNEY DISEASE
Over the last decade, it has become evident that patients with chronic kidney disease (CKD) are at high risk of developing neurocognitive impairment, which may influence medication/dietary adherence and quality of life. I ... -
The Influence of Movement Costs on Search Behaviour
Humans regularly search their environment for an object to grasp through movements of the eye, head, and body. While search behaviour in humans has been well-studied, there has been little work which has investigated if ... -
Experiencing Virtual Reality: The Impact of Motion Parallax and Binocular Disparity on Presence, Cybersickness, and Restoration
The main goal of virtual reality devices is to provide virtual environments where users experience a high level of presence, less cybersickness and suitable for many applications. One of the main applications that has ... -
MONOSODIUM GLUTAMATE INCREASES VISCERAL SENSITIVITY IN A PRECLINICAL MODEL OF IRRITABLE BOWEL SYNDROME
Patients with irritable bowel syndrome (IBS) have identified that monosodium glutamate (MSG) triggers symptoms of abdominal pain. I sought to use a preclinical model for IBS to study how MSG effects intestinal afferent ... -
Characterization of the Biomechanical and Situational Aspects of High Magnitude Subconcussive Impacts in Canadian University Football
Background: Subconcussive impacts are asymptomatic head impacts that induce alterations in the brain after repetitive exposure. Understanding factors that lead to higher magnitude or frequency of subconcussive head impacts ... -
Release of a proposed activator of spreading depolarization by abrupt hyperthermia
Spreading depolarization (SD) is a wave of lost membrane potential moving across the gray matter within 1-2 minutes of metabolic compromise as during stroke, post-injury fever or migraine aura. Research is ongoing to protect ... -
A PILOT STUDY: AN OPEN-LABEL BIOMARKER DEVELOPMENT OF KETAMINE FOR UNIPOLAR REFRACTORY DEPRESSION
Objective: The primary objective of this study is to evaluate the antidepressant efficacy of an acute intravenous subanesthetic ketamine treatment (0.5 mg/kg) for patients with unipolar treatment-resistant depression (TRD). ... -
Robotic Assessment to Detect Neurological Impairments Associated with Transient Ischemic Attack
Transient ischemic attacks (TIA) are a substantial risk factor for ischemic stroke, but have been widely regarded as minor perturbations to the function of the central nervous system that leave little to no lasting impact ... -
Fura-2 Calcium Imaging Is a Valid Method of Investigating Signalling & Integrative Properties of the Subfornical Organ
Research into the integration of signalling molecules at the subfornical organ (SFO) is typically conducted through in vitro electrophysiology methods on dissociated SFO neurons. We performed Fura-2 calcium imaging on ... -
Nurturing the Seed: A Collaborative Journey to Infant Mental Health and Wellness: Phase One
Despite the known value of culturally meaningful practice in supporting mental health in Indigenous communities, there lacks culturally informed developmental assessment tools and interventions. Nurturing the Seed was ... -
The Influence of Catecholamines on Working Memory and the Activational Aspects of Motivation
Catecholamines are thought to have a major modulatory effect on cognition. However, there is only equivocal evidence that catecholamines have a direct impact on cognition. A body of research suggests that catecholamines ... -
Acute Physiological Effects of Brain-Generated 17β-Estradiol in the Rodent Primary Auditory Cortex
The neuroactive steroid hormone 17β-estradiol (E2) modulates synaptic activity and plasticity in both endocrine and non-endocrine forebrain regions of males and females of a variety of species. Research conducted in songbirds ... -
Low-Intensity Cognitive Behavioural Therapy-Based Music Groups for the Treatment of Mild to Moderate Symptoms of Mental Illness
The costs of mental illness - economic, social, and human - are immense. However, the demand for evidence-based non-pharmaceutical therapies appears to exceed the availability of these services, and when therapy is available, ...
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