Neuroscience Studies (CNS), Centre for
The Centre for Neuroscience Studies is a hub of multidisciplinary research and teaching aimed at improving our understanding of the brain, how it works and how new therapies and diagnoses can play an important role in the prevention and treatment of diseases like Parkinson’s, Alzheimer’s, Stroke, Obesity, Fetal Alcohol Spectrum Disorder, Schizophrenia, Behavioral Disorders, Depression to name a few.
This community includes research outputs produced by faculty and students. Submitting works to QSpace may enable compliance with the Tri-Agency Open Access Policy on Publications.
When you submit your work to QSpace, you retain copyright and grant the Library a non-exclusive license to distribute and preserve. Works are open access unless restricted by the creator.
Collections in this community
Recent Submissions
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Poor Regional Cerebral Oxygenation During Critical Illness May Be Associated With Acute and Chronic Neurological Dysfunction
Survivors of critical illness frequently exhibit acute (i.e., delirium) and chronic neurological complications. Intensive care unit prevalence of delirium is as high as 80% and has been associated with increased length of ... -
Neural Processing in Primary Motor Cortex and its Relationship to Contralateral and Ipsilateral Motor Actions
The role of primary motor cortex (M1) in controlling movements has been a long-debated subject because M1 neurons have been shown to relate to many different aspects of motor control. A confounding issue is that different ... -
Confidence intervals and measures of significant change for KINARM Standard Tests
Neurological assessment plays a pivotal role in the overall diagnostic and prognostic process of patient care. The effectiveness of the various examinations and methods of neurological assessment are based on the accuracy ... -
Frequency & Magnitude of Helmet Impacts in One Season of Collegiate Football: An Investigation Into the Effect of Session and Position Type
Background: Concussive and subconcussive head impacts play important roles in long-term brain health. Professional and collegiate football leagues have been taking steps to reduce dangerous and injurious hits during games, ... -
Estrogens in the bed nucleus of the stria terminalis: State-dependent modulation of inhibitory synaptic transmission in rats
Beyond their important role in reproduction, estrogens contribute in various adaptive and maladaptive physiological phenomena including, but not limited to, appetite, stress response, and the development of compulsive ... -
Neuromodulatory and metaplastic regulation of long-term synaptic plasticity in the primary visual cortex of adult rats.
Synaptic plasticity in the neocortex of mammals is influenced by various neuromodulators and metaplasticity mechanisms. These regulatory processes allow synaptic networks to operate and adjust to various behavioral states ... -
Understanding the neurobiological basis of mixed-strategy decision-making in health and disease
During competitive interactions involving multiple agents, such as sporting competitions, the outcome of each individual’s actions is dependent not only on a historical sequence of their own choices, but on those of ... -
EXAMINING THE NEURAL AND COGNITIVE PROCESSES UNDERLYING TYPICAL AND ATYPICAL READING ABILITY
Although reading is an important and generative skill that is important for a child’s future academic, economic, and social success, it remains controversial how it develops and what leads to reading difficulties. Furthermore, ... -
Qualitative evaluation of an anti-stigma intervention to reduce the impact of stigma in individuals with mental illness
Objectives: To evaluate the effectiveness of a group-based, psychoeducational and behavioural modification intervention, Overcoming Stigma in Mood and Anxiety Disorders, in reducing the impact of mental-illness-related ... -
Stress-Related Effects of Phoenixin on Nucleus of the Solitary Tract Neurons
Phoenixin (PNX) is a recently discovered neuropeptide that was initially determined to positively contribute to reproductive functioning. Since its discovery, however, PNX has been implicated in a diverse range of physiological ... -
Change in a person's cognitive/emotional state, including expecting pain, is linked to connectivity change in identified brainstem and spinal cord networks
Resting-state functional MRI examines activity of the central nervous system in the absence of a specific task or stimulus, and has been used to investigate coordinated activity within the cerebral hemispheres, as well as ... -
Neuropsychiatric-like behavioural features of the Aldh2-/- mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is a complex, multifaceted neurodegenerative disorder characterized by progressive memory impairment and frequently presents with neuropsychiatric comorbidities, notably anxiety and depression. We ... -
Neuropeptides in the Bed Nucleus Stria Terminalis: Implications in Chronic Stress
For the last 20-30 years, new discovery of pharmacological treatment for psychiatric disorders has been stagnant despite a pressing need to find alternative therapies for patients that are treatment-resistant to the current ... -
Tumor necrosis factor alpha influences the excitability of subfornical organ neurons and potentiates angiotensin II-induced calcium activity
Cardiovascular disease is a leading cause of mortality worldwide. Progress has been made in diagnosing and treating this condition, however the mechanisms by which it develops have yet to be fully elucidated. Accumulating ... -
Modeling Subfornical Organ Neurons
Subfornical organ (SFO) neurons exhibit heterogeneity in ionic current expression and spiking behaviour, where the two major phenotypes appear as tonic and burst firing. Insight into the mechanisms behind this heterogeneity ... -
Correlating Sympathetic and Parasympathetic Control of Saccade Behaviour
The autonomic nervous system controls numerous effectors within the human body, working to adapt to changing environments. It is composed of three divisions: the sympathetic, parasympathetic, and enteric nervous systems. ... -
Regional Differences in Na+/K+-ATPase Expression in the Mouse and Rat Brain
Insufficient blood flow to the brain generates widespread neurological damage, yet not all brain regions are similarly vulnerable to ischemic injury. During stroke, failure of the Na+/K+-ATPase generates a robust anoxic ... -
Interval Versus Continuous Cognitive Training in Schizophrenia: Comparing Cognitive, Neurophysiological, and Subjective Outcomes
Background: Therapies aimed at remediating cognitive deficits in schizophrenia vary widely in their approach and delivery of cognitive training. In healthy populations, rest breaks have been shown to improve attention, ... -
Eye Movement Control as a Functional Biomarker of Brain Development in the Child Welfare Population
Background: Prenatal Alcohol Exposure (PAE) can result in a continuum of neurological, behavioural, physical and learning deficits collectively referred to as fetal alcohol spectrum disorder (FASD). Eye movement tasks have ... -
Examining Sex Differences in Hippocampal Theta Activity in Relation to Anxiety-Like Behaviours in Rats
Hippocampal theta activity is an oscillatory, highly rhythmic (4-14 Hz) activity pattern generated by the hippocampal formation of mammals. Theta activity has been linked to anxiety states in rodent, based on a number of ...
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