Neuroscience Studies (CNS), Centre for
The Centre for Neuroscience Studies is a hub of multidisciplinary research and teaching aimed at improving our understanding of the brain, how it works and how new therapies and diagnoses can play an important role in the prevention and treatment of diseases like Parkinson’s, Alzheimer’s, Stroke, Obesity, Fetal Alcohol Spectrum Disorder, Schizophrenia, Behavioral Disorders, Depression to name a few.
This community includes research outputs produced by faculty and students. Submitting works to QSpace may enable compliance with the Tri-Agency Open Access Policy on Publications.
When you submit your work to QSpace, you retain copyright and grant the Library a non-exclusive license to distribute and preserve. Works are open access unless restricted by the creator.
Collections in this community
Recent Submissions
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Interval Versus Continuous Cognitive Training in Schizophrenia: Comparing Cognitive, Neurophysiological, and Subjective Outcomes
Background: Therapies aimed at remediating cognitive deficits in schizophrenia vary widely in their approach and delivery of cognitive training. In healthy populations, rest breaks have been shown to improve attention, ... -
Eye Movement Control as a Functional Biomarker of Brain Development in the Child Welfare Population
Background: Prenatal Alcohol Exposure (PAE) can result in a continuum of neurological, behavioural, physical and learning deficits collectively referred to as fetal alcohol spectrum disorder (FASD). Eye movement tasks have ... -
Examining Sex Differences in Hippocampal Theta Activity in Relation to Anxiety-Like Behaviours in Rats
Hippocampal theta activity is an oscillatory, highly rhythmic (4-14 Hz) activity pattern generated by the hippocampal formation of mammals. Theta activity has been linked to anxiety states in rodent, based on a number of ... -
Neural Correlates of Saccade Target Selection and Programming in Superior Colliculus
Decision-making process involves sequential stages of sensory processing, perceptual selection of a target for the behavior, preparation of an action, and execution of that action. Superior colliculus is at the center of ... -
Probing The Link Between Indolent Aneurysm Dome Infection And Brain Aneurysm Growth And Rupture.
Background: Vascular inflammation and immune activation play important roles in intracranial aneurysm (IA) pathology. From mycotic aneurysms it is apparent that fulminant microbial infection can drive aneurysm formation ... -
Novel Assessment Tool for Fetal Alcohol Spectrum Disorder (FASD) Based on Eye Movement Behaviours
Fetal alcohol spectrum disorder (FASD) is the leading cause of preventable developmental disability among Canadians, affecting at least 1% of the population. Diagnosis of FASD requires collaboration from a multidisciplinary ... -
Spreading Depolarization Evoked by Oxygen-Glucose Deprivation or by Temperature Change in Frog and Rat Brain Slices
As a result of anoxia or abrupt change in temperature spreading depolarizations (SD) occur in the grey matter of the higher brain, promoting neuronal injury. SD in mammals and insects induces a sudden shutdown of the ... -
Spreading Depolarization in the Early Post-Ischemic Brain
Stroke is one of the leading causes of death and long-term disability throughout developed countries. A propagating wave of mass depolarization of neurons and glia, referred to as spreading depolarization (SD), occurs ... -
Microbial Modulation of Nociception
Peripheral pain signaling reflects a balance of pro and anti-nociceptive influences; the contribution by the gastrointestinal (GI) microbiota to this balance has received little attention. GI disorders such as inflammatory ... -
The Effects of Intermittent Theta Burst Stimulation on Working Memory in Depressed Patients
Background: People with depression struggle with cognitive impairments such as decreased working memory. The brain areas associated with working memory, such as the prefrontal cortex and hippocampus are negatively affected ... -
Transsaccadic Memory of Multi-Featured Objects
Our visual world is observed as a complete and continuous percept. However, the nature of eye movements, saccades, preclude this illusion at the sensory level of the retina. Current theories suggest that visual ... -
Adropin Acts in the Paraventricular Nucleus of the Hypothalamus to Influence Neuronal Excitability
Adropin is a peptide hormone with cardiovascular and metabolic roles in the periphery, including effects on glucose and lipid homeostasis. Central administration of adropin has been shown to inhibit water intake in rats; ... -
The Effects of Transcranial Magnetic Stimulation on Depression and the Associated Olfactory Dysfunction
Introduction: Depression negatively impacts olfactory functioning and as such, olfactory dysfunction has been found in individuals with depression. Expansions of this research have demonstrated an improvement in olfactory ... -
Using Eye Movements to Establish a Normative Database of Control Participants Across the Lifespan
As the brain develops and ages, cognitive abilities (e.g., attention and memory) undergo significant functional fluctuations. In order to differentiate neuropathology from natural changes that occur due to development and ... -
Epigenetic Modification of Phenotype in Intestinal Smooth Muscle Cells
Inflammation causes proliferation of intestinal smooth muscle cells (ISMC), contributing to the thickened intestinal wall and the dysmotility symptoms observed in inflammatory bowel disease (IBD). A unique consequence of ... -
Differential Na+/K+ Pump Isoform Expression in Higher and Lower Brain Regions of the Mouse
It has been demonstrated both clinically and experimentally that the higher brain is highly vulnerable to ischemia, while the lower brain is comparatively resilient. Discovering how lower brain neurons naturally resist ... -
The Subfornical Organ: A Novel Site for Prolactin Action
Prolactin (PRL) is a peptide hormone which performs over 300 biological functions, including those that require binding to prolactin receptor (PRL-R) in neurons within the central nervous system (CNS) (Bole-Feysot, Goffin, ... -
Characterization of the Circadian Rhythm of Pain in Naive and Neuropathic Mice
Neuropathic pain is defined as “pain caused by a lesion or disease of the nervous system”. Neuropathic pain conditions are estimated to affect up to 8% of the population worldwide and presently, the most common treatment ... -
The effect of anti-saccade training on cognitive function in healthy adults and Parkinson's disease patients
Our novel study investigated how the anti-saccade training can influence cognitive capabilities of healthy and Parkinson’s disease participants. The rationale is that the anti-saccade task requires top-down control and ... -
Efficacy of using robotics to characterize impaired upper-limb function in a non-human primate model of stroke
Rationale: Stroke is a leading cause of death and disability and has the largest socioeconomic burden of any disease in Canada. Unfortunately, thousands of stroke therapies that proved successful in animal preclinical ...
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