Neuroscience Studies (CNS), Centre for
The Centre for Neuroscience Studies is a hub of multidisciplinary research and teaching aimed at improving our understanding of the brain, how it works and how new therapies and diagnoses can play an important role in the prevention and treatment of diseases like Parkinson’s, Alzheimer’s, Stroke, Obesity, Fetal Alcohol Spectrum Disorder, Schizophrenia, Behavioral Disorders, Depression to name a few.
This community includes research outputs produced by faculty and students. Submitting works to QSpace may enable compliance with the Tri-Agency Open Access Policy on Publications.
When you submit your work to QSpace, you retain copyright and grant the Library a non-exclusive license to distribute and preserve. Works are open access unless restricted by the creator.
Collections in this community
Recent Submissions
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MONOSODIUM GLUTAMATE INCREASES VISCERAL SENSITIVITY IN A PRECLINICAL MODEL OF IRRITABLE BOWEL SYNDROME
Patients with irritable bowel syndrome (IBS) have identified that monosodium glutamate (MSG) triggers symptoms of abdominal pain. I sought to use a preclinical model for IBS to study how MSG effects intestinal afferent ... -
Characterization of the Biomechanical and Situational Aspects of High Magnitude Subconcussive Impacts in Canadian University Football
Background: Subconcussive impacts are asymptomatic head impacts that induce alterations in the brain after repetitive exposure. Understanding factors that lead to higher magnitude or frequency of subconcussive head impacts ... -
Release of a proposed activator of spreading depolarization by abrupt hyperthermia
Spreading depolarization (SD) is a wave of lost membrane potential moving across the gray matter within 1-2 minutes of metabolic compromise as during stroke, post-injury fever or migraine aura. Research is ongoing to protect ... -
A PILOT STUDY: AN OPEN-LABEL BIOMARKER DEVELOPMENT OF KETAMINE FOR UNIPOLAR REFRACTORY DEPRESSION
Objective: The primary objective of this study is to evaluate the antidepressant efficacy of an acute intravenous subanesthetic ketamine treatment (0.5 mg/kg) for patients with unipolar treatment-resistant depression (TRD). ... -
Robotic Assessment to Detect Neurological Impairments Associated with Transient Ischemic Attack
Transient ischemic attacks (TIA) are a substantial risk factor for ischemic stroke, but have been widely regarded as minor perturbations to the function of the central nervous system that leave little to no lasting impact ... -
Fura-2 Calcium Imaging Is a Valid Method of Investigating Signalling & Integrative Properties of the Subfornical Organ
Research into the integration of signalling molecules at the subfornical organ (SFO) is typically conducted through in vitro electrophysiology methods on dissociated SFO neurons. We performed Fura-2 calcium imaging on ... -
Nurturing the Seed: A Collaborative Journey to Infant Mental Health and Wellness: Phase One
Despite the known value of culturally meaningful practice in supporting mental health in Indigenous communities, there lacks culturally informed developmental assessment tools and interventions. Nurturing the Seed was ... -
The Influence of Catecholamines on Working Memory and the Activational Aspects of Motivation
Catecholamines are thought to have a major modulatory effect on cognition. However, there is only equivocal evidence that catecholamines have a direct impact on cognition. A body of research suggests that catecholamines ... -
Acute Physiological Effects of Brain-Generated 17β-Estradiol in the Rodent Primary Auditory Cortex
The neuroactive steroid hormone 17β-estradiol (E2) modulates synaptic activity and plasticity in both endocrine and non-endocrine forebrain regions of males and females of a variety of species. Research conducted in songbirds ... -
Low-Intensity Cognitive Behavioural Therapy-Based Music Groups for the Treatment of Mild to Moderate Symptoms of Mental Illness
The costs of mental illness - economic, social, and human - are immense. However, the demand for evidence-based non-pharmaceutical therapies appears to exceed the availability of these services, and when therapy is available, ... -
The Safety, Efficacy, and Tolerability of Microbial Ecosystem Therapeutic-2 in People with Major Depression and/or Generallzed Anxiety Disorder
Objective: The primary objective of this study is to assess subjective changes in mood and anxiety symptoms before, during, and after administration of the microbial therapeutic. The secondary objectives of this study are ... -
Effects of the Gut Microbiota on Intestinal Function
A growing emphasis has been placed on the importance of the gut-brain axis (GBA) and its role in normal physiological functions of the body. This bidirectional axis links cognitive functions of the central nervous system ... -
Investigating the association between cortical morphological features and the properties of underlying WM tracts in healthy young adults
Quantitative measures of gray matter (GM) and white matter (WM) can be derived from structural and diffusion Magnetic Resonance Imaging (MRI) to study the cerebral cortex and WM projections. Previous multimodal research ... -
Developing and Employing a Behavioral Platform to Characterize a non-human Primate Model of Alzheimer's Disease
Alzheimer’s disease (AD) is a devastating neurodegenerative disease and with shifting demographics, the number of affected individuals is estimated to increase dramatically. While a great deal of resources has been dedicated ... -
Coding body and world for reaching movements
To reach to visual targets, we need to transform the visual representation into the coordinate system of the moving arm, i.e. coordinate transformations. Varying body postures such as lying or rolling the head leads to ... -
The effects of subconcussive impacts on white matter integrity in the corpus callosum and corticospinal tracts
Over the course of a football season the athletes are subject to a large number of impacts ranging in magnitude. With these impacts failing to cause any clinical signs of concussion, they often get disregarded as non-injurious. ... -
Partial Molecular and Biochemical Characterization of a Sandhoff Mouse Model
Sandhoff Disease (SD) is a rare genetic disorder which results in progressive neurodegeneration. SD is caused by a build-up of GM2 Gangliosides, a lipid which is stored in the lysosome of neurons. It can occur in infantile, ... -
Motor Memories in Manipulation Tasks are Linked to Contact Events Between Objects
Humans have the remarkable ability to learn and perform motor skills, often involving the manipulation of different objects or tools, such as swinging a hammer or a tennis racket. The objects that we manipulate are usually ... -
Neural correlates and effects of increased cognitive load on performance during the n-back task in major depressive disorder
Background: Major depressive disorder (MDD) is a heterogenous disease that includes debilitating cognitive deficits, including working memory (WM). The n-back task used to examine WM as it requires continuous updating and ... -
Preclinical Assessment of Intravenous Gene Therapy for GM2 Gangliosidosis
GM2 Gangliosidoses are a group of severe neurodegenerative lysosomal storage disorders characterized by the inability to catabolize GM2 Gangliosides, leading to a neurotoxic accumulation of the GM2 lipids within the central ...
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