Neuroscience Studies (CNS), Centre for
The Centre for Neuroscience Studies is a hub of multidisciplinary research and teaching aimed at improving our understanding of the brain, how it works and how new therapies and diagnoses can play an important role in the prevention and treatment of diseases like Parkinson’s, Alzheimer’s, Stroke, Obesity, Fetal Alcohol Spectrum Disorder, Schizophrenia, Behavioral Disorders, Depression to name a few.
This community includes research outputs produced by faculty and students. Submitting works to QSpace may enable compliance with the Tri-Agency Open Access Policy on Publications.
When you submit your work to QSpace, you retain copyright and grant the Library a non-exclusive license to distribute and preserve. Works are open access unless restricted by the creator.
Collections in this community
Recent Submissions
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Electrophysiology of memory consolidation and epileptogenesis in the primate mesial temporal lobe. Effects of focal seizures with impaired awareness
Epilepsy is a disorder characterized by unprovoked, recurrent seizures and affects approximately 350,000 Canadians. A third of this population have seizures that are refractory. This leaves over 100,000 people with ... -
Cognitive and Affective Control of Pain in the Human Brain and Brainstem Revealed by Means of Functional MRI and Analyses of Network Connectivity
Pain is a complex individual experience that involves sensory/discriminative, motor, autonomic, and cognitive/affective components. Acute pain permeates the human experience, and chronic pain is highly prevalent and costly ... -
Olfactory Bulb Proteome Changes in Response to Alzheimer's Disease-Related Pathologies in Mouse and Rat Models
Alzheimer’s disease (AD) is the most common cause of dementia, and it is one of the leading causes of death globally. Identification and validation of biomarkers that herald the onset and progression of AD is of paramount ... -
Examining the Neural Correlates of Peer Victimization and Peer Defending Using Functional Magnetic Resonance Imaging
Peer victimization is associated with psychosocial difficulties and mental health challenges. The neurobiological mechanisms underlying this association have yet to be fully understood. This dissertation is composed of ... -
The Dp16 Mouse Model of Down Syndrome: Phenotypic Characterization and Assessment of the Pro-Cognitive Agent RIV5061
Although there are many factors which can influence the development of Alzheimer’s disease (AD), the greatest non-genetic and genetic risk factors are aging and Down syndrome (DS), respectively. The Aldh2-/- mouse model ... -
Characterization of a Putative Molecular Activator of Spreading Depolarization Generated by the Ischemic Brain
Immediately following brain ischemia, failure of the Na+/K+-ATPase leads to a formidable inward cationic current through an unidentified channel which drives spreading depolarization (SD). Recurrent SD events contribute ... -
Art-Based Rehabilitation Training (ART) for Upper Limb Sensorimotor Recovery Post Stroke: A 2-Phase Pilot Study
High repetitions of task-oriented practice are essential to drive functional recovery of the upper limb (UL) after stroke. Unfortunately, therapy time focused on the upper limb is limited and movement repetitions are low ... -
The Design and In-Vitro Validation of Therapeutic CRISPR Base Editing and AAV-9 Gene Therapy for the Treatment of Classic Galactosemia
Classic Galactosemia (CG) is a potentially fatal genetic metabolic illness characterized by the inability to effectively metabolize galactose. This disease manifests as various neurological, reproductive, and systemic ... -
Training Considerations and Implementation of Robotic Assessments of Upper Limb Function in A Nonhuman Primate Model of Chronic Stroke
During the development of potential stroke therapies, preclinical studies using animal models are crucial for evaluating safety and efficacy prior to human clinical trials. In designing preclinical studies, there are a ... -
Robotic assessment of sensorimotor and cognitive deficits in patients with epilepsy
Individuals with temporal lobe epilepsy (TLE) can present with significant cognitive impairments, such as impaired executive function, working memory, and declarative memory. Traditionally, these impairments are assessed ... -
Characterizing the Effects of Subconcussive Impact Biomechanics on Resting-State Brain Hemodynamics and Functional Connectivity
Background: The study of impact biomechanics in contact sports has improved our current understanding of concussion mechanisms and the cumulative effects of subconcussive impacts on brain health. Impact exposure is often ... -
Intrathecal Delivery of a Human Bicistronic Hexosaminidase Vector to Correct Sandhoff Disease in a Murine Model: A Dose-Response Study
GM2 gangliosidosis is a group of lysosomal storage disorders including Tay-Sachs disease (TSD), Sandhoff disease (SD), and the AB variant of GM2 gangliosidosis. TSD and SD are characterized by reduced or absent levels of ... -
Investigating the Neural Basis of Pain Sensitivity in Fibromyalgia Using Functional Magnetic Resonance Imaging
Fibromyalgia (FM) is a chronic pain condition that is estimated to affect 2-5% of the global population. The cause of FM is currently unknown, although most evidence suggests it involves central sensitization. To determine ... -
An Investigation of Neural Responses to the Anticipation and Experience of Pain in Humans, Revealed by Functional Magnetic Resonance Imaging of the Brainstem and Spinal Cord
Pain is a complex, highly subjective phenomenon in humans and the brainstem and spinal cord serve fundamental roles in the processing and modulation of ascending nociceptive signals. Emotional-cognitive factors such as ... -
Investigating the effect of subconcussive impact exposure on white matter integrity in collegiate football players
Background: Recently, there has been growing concern around subconcussive impacts (SCI) in football and the potential implications on neurologic health. Of particular interest are athletes who undergo repeated exposure to ... -
The role of ErbB inhibitors in promoting nerve regeneration in a mouse model of nerve injury
Nerve injury is a common clinical challenge that has a considerable impact on an individual’s quality of life and function. Despite multiple surgical strategies, functional outcomes following nerve injury remain poor. ... -
Characterizing the association between regional cerebral oxygen saturation and neurological impairment after cardiac surgery
It is well-known that patients undergoing cardiac surgery are at risk of developing acute, fluctuating (i.e. delirium), and/or long-term post-operative neurological complications. Incidence of neurological impairment can ... -
A Refined Spatiotemporal Analysis of Extracellular Waveforms From Neurons Within the Lateral Intraparietal Area of the Macaque Posterior Parietal Cortex
Extracellular spike waveforms recorded from neurons are known to reflect the intracellular process of action potential generation through the activation and inactivation of ion channels. The variability between the shape ... -
Regulation of the intestinal smooth muscle cell phenotype by the antifibrotic drug nintedanib
The phenotype of the intestinal smooth muscle cell (ISMC) is typically contractile and non- proliferative, but this can be modulated to allow for proliferation as a wound repair mechanism. While phenotypic modulation of ... -
Investigating the Clinical Effects and Mechanistic Underpinnings of Probiotics on Major Depressive Disorder
Background: Probiotics have been hypothesized to improve symptoms of Major Depressive Disorder (MDD). Evidence suggests that these outcomes may be driven by probiotics reducing inflammation and regulating neurotransmission ...
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