Show simple item record

dc.contributor.authorDhamija, Prateeken
dc.date.accessioned2017-05-17T14:51:05Z
dc.date.available2017-05-17T14:51:05Z
dc.identifier.urihttp://hdl.handle.net/1974/15853
dc.description.abstractStressful experiences during youth can lead to a maladaptive behaviour profile in adulthood, including an increase in anxiety and aggression-related behaviours in humans. Rats exposed to the intermittent physical stress (IPS) paradigm in early-adolescence (PD 22 – 34) have lasting increases in anxiety-related behaviour. Greater anxiety-related behaviours have been shown to be associated with greater aggression-related behaviours. Therefore, I hypothesized that stress during early-adolescence would also lead to increases in aggression. In addition, greater anxiety and aggression have been associated with altered serotonergic function in the prefrontal cortex and ventral hippocampus. However, it is unclear whether a similar mechanism accounts for the enduring impact of stress during adolescence on those responses. In this experiment, I examined if IPS during early-adolescence increased anxiety-related behaviour in the elevated plus-maze and shock-probe burying test, as well as increased aggressive behaviour in the resident intruder test. In addition, I determined if there were changes in serotonin fibre density in the prefrontal cortex and ventral hippocampus. Male Long Evans rats (N = 24) were randomly assigned to either the early-adolescent stress or no-stress control groups. Rats were exposed to IPS stress (involving foot-shock, water immersion and elevated platform exposure) during early-adolescence and tested in the elevated plus-maze, shock-probe burying test and resident intruder test in adulthood. At the end of behavioural testing, brain tissue was examined for serotonin fibre density in the regions of interest using immunohistochemistry. Animals exposed to early-adolescent stress did not display greater levels of anxiety; however, they did display lower levels of aggression and an increase in serotonin fibre density in the prefrontal cortex. These results support that early-adolescence is a period of vulnerability of emotional development and raise the possibility that the impact of stress in adolescence on aggression in later life depends on when the stressors were experienced.en
dc.language.isoengen
dc.relation.ispartofseriesCanadian thesesen
dc.rightsCC0 1.0 Universalen
dc.rightsQueen's University's Thesis/Dissertation Non-Exclusive License for Deposit to QSpace and Library and Archives Canadaen
dc.rightsProQuest PhD and Master's Theses International Dissemination Agreementen
dc.rightsIntellectual Property Guidelines at Queen's Universityen
dc.rightsCopying and Preserving Your Thesisen
dc.rightsThis publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.en
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjectPsychologyen
dc.subjectSerotoninen
dc.subjectStressen
dc.subjectDevelopmenten
dc.subjectAdolescenten
dc.subjectAdolescenceen
dc.subjectAnxietyen
dc.subjectAnimal-Modelen
dc.subject5-HTen
dc.subjectAggressionen
dc.titleStress During Early-Adolescence Reduces Rats’ Aggression and Increases Their Serotonin Fibre Density in Adulthooden
dc.typethesisen
dc.description.degreeM.Sc.en
dc.contributor.supervisorMenard, Janet L.en
dc.contributor.departmentPsychologyen
dc.degree.grantorQueen's University at Kingstonen


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC0 1.0 Universal
Except where otherwise noted, this item's license is described as CC0 1.0 Universal