Browsing Graduate Theses, Dissertations and Projects by Title
Now showing items 628-647 of 6345
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The calling of an engineer: High school students' perceptions of engineering
(2016-01-11)The focus of this research study was to provide insight into high school students’ perceptions of engineering and the work engineers do. Participants included Grades 9 and 10 students, all of which were enrolled in academic ... -
“A Calm Arises”: An Anxious Adolescent’s Experience of Building Self-Compassion Through Aesthetic Reading
In recent years, the Ontario Government (2013) has recognized that schools have a vital role in facilitating the prevention, intervention, and awareness of student mental wellness. Increased political attention to student ... -
The Calmodulin-Like Protein CML42 is Involved in Trichome Branching in Arabidopsis
(2009-09-16)The Snedden lab has been studying a family of Ca2+-binding proteins from Arabidopsis that are related to the prototypical Ca2+ sensor calmodulin (CaM) and are termed CMLs (CaM-like proteins). Previous work on CML42 ... -
CALPAIN 2 ACTIVATION, AUTOLYSIS, AND SUBUNIT DISSOCIATION
(2010-10-25)Calpains are calcium-dependent, intracellular, multi-domain cysteine proteases involved in many physiological functions regulated by calcium signaling, including cell motility. How calpains are activated in the cell is ... -
Calpain inhibitor design inspired by the natural inhibitor calpastatin
(2014-11-07)Calpains are cysteine proteases that depend on Ca2+ for activation. They have many roles in the cell; hence modifications of calpains or changes in their levels of activity can lead to altered physiological states. Thus, ... -
The Calpain Protease Active Site: A Target for Inhibitor and Activity-Based Probe Design
(2008-09-04)The calpain family of intracellular Ca2+-dependent cysteine proteases is involved in a number of intracellular signaling processes. Calpain hyperactivity has also been implicated in ischemic injury, neurodegenerative ... -
Calpain-1 and Calpain-2 Promote HER2/NEU Tumorigenesis and Independently Promote Metastasis in Triple Negative Breast Cancer
Calpains are a family of calcium activated cysteine proteases. Calpain-1 and calpain-2 are obligate heterodimers composed of isoform specific catalytic subunits (encoded by capn1 and capn2, respectively) coupled with the ... -
CALPAIN: TRANSITIONING FROM THE USE OF THE PROTEASE CORE TO THE FULL-LENGTH ENZYME FOR THE DEVELOPMENT OF SPECIFIC SUBSTRATES AND INHIBITORS
(2008-09-27)Calpains are a family of calcium-dependent cysteine proteases involved in intracellular signaling. They participate in many normal cellular processes such as cell motility and apoptosis but when over-activated they contribute ... -
"The Camera Cannot Lie": Photography and the Pacific Non-Fiction of Robert Louis Stevenson (1888-1894)
(2014-04-07)This archivally-based dissertation re-contextualizes Robert Louis Stevenson’s South Pacific photographic collection (1888-1894), situating it in relation to his incomplete and posthumously published anthropological study ... -
Can genomic tools aid conservation of an arctic seabird, the northern fulmar (Fulmarus glacialis)?
Human activities and climate change threaten Arctic ecosystems. Population genetics and genomics may help conservationists appropriately manage threatened species both by (1) determining the population genetic structure ... -
Can Infants Use Transitive Inference in Attribution of Goals to Others?
(2012-08-14)Transitive inference refers to the ability to use knowledge of pre-existing relationships to infer relationships between entities that have not been directly compared. This form of logical inference is an important skill ... -
Can Mental Health Education Using a Storybook Reduce Mental Illness Stigma in Children?
(2013-07-03)Individuals experiencing a mental illness are often stigmatized. Children also stigmatize those who experience a mental illness. There is national interest in reducing the negative effects of stigma, especially in children. ... -
Can Rural Communities Support Aging Populations? A Case Study in South Frontenac Township, Ontario, Canada
When planning for care for the aging population, the aging-in-place movement aims to keep older adults at home if possible – but how feasible is this method for the rural population? Previous research has shown that rural ... -
Can sedentary time attenuate the acute effect of exercise on insulin action?
(2014-08-21)Impaired insulin action predicts the development of type 2 diabetes. Evidence is growing that sedentary time (SED) is a risk factor for morbidity and mortality, independent of moderate to vigorous physical activity (MVPA) ... -
Can the Single-Leg Hop Distinguish Between ACL Reconstructed Individuals and Controls
Anterior cruciate ligament (ACL) injuries are common orthopedic injuries (Sanders et al., 2016). Following reconstruction of the ACL a patient must be medically cleared before returning to full participation in sport or ... -
"Can you ask her to help?" An examination of the factors that promote and discourage prosocial intervention in preschool children
(2016-08-25)Previous research has examined young children’s ability to detect who would be most likely to provide help to others in a given situation, but little is known about their ability to intervene based on this knowledge in a ... -
Canada's Other Red Scare: rights, decolonization, and Indigenous political protest in the global sixties
(2011-05-30)This dissertation examines the histories of Indigenous protest, commonly known as “Red Power,” in the 1960s and 1970s in the town of Kenora, Ontario. Among the themes discussed are the associations of Indian and Métis ... -
Canada, the United States and the Command and Control of Air Forces for Continental Air Defence from Ogdensburg to NORAD, 1940-1957
(2009-12-14)This dissertation examines the evolution of the bilateral Canadian-American continental air defence operational-level command and control relationship from the 1940 Ogdensburg Agreement to the establishment of the North ... -
The Canadian Carceral State: Violent Colonial Logics of Indigenous Dispossession
(2016-04-11)This thesis examines the over-representation of indigenous women in Canadian federal prisons. I situate the prison as a site of modernity to draw attention to the ways that the prison is underpinned by the logics of white ... -
Canadian Football League Stadium Location: A Comparative Analysis of the Saskatchewan Entertainment Facility and Winnipeg Stadium
(2011-04-25)This report offers a comparison of the planning for two professional football stadia in Canada. The development of a new stadium has long-term consequences on a city’s land use pattern and economic activity. Although ...