Browsing Graduate Theses, Dissertations and Projects by Title
Now showing items 4518-4537 of 6609
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p53 Regulates the Formation of Lamellipodia and Circular Dorsal Ruffles Through Caldesmon and PTEN
(2011-06-14)Vascular smooth muscle cell migration is a significant contributor to many aspects of heart disease, and specifically atherosclerosis. Tissue damage in the arteries can result in the formation of a fatty streak. Smooth ... -
PA3719-Mediated Regulation of the MexAB-OprM Efflux System of Pseudomonas aeruginosa
(2007-09-26)Intrinsic antimicrobial resistance of the opportunistic human pathogen Pseudomonas aeruginosa has mainly been attributed to the presence of several chromosomally-encoded multidrug efflux systems. The MexAB-OprM system ... -
PA5471 modulation of the Pseudomonas aeruginosa mexXY multidrug efflux pump operon repressor MexZ: Identification of important interaction residues and domains
(2013-02-26)Chemotherapeutic treatment of Pseudomonas aeruginosa, a Gram-negative opportunistic pathogen, is substantially challenged by several membrane-spanning, multidrug-efflux pumps of the three-component RND family. Of these ... -
Pack Level Design Optimization for Electric Vehicle Thermal Management Systems Minimizing Standard Deviation of Temperature Distribution
(2013-10-30)Green technologies have recently gained interest for many reasons. Economic factors in conjunction with an increased social desire to reduce our environmental impact on the Earth have created a desire for more environmentally ... -
Packaging and Layout Optimization Using the Dynamic Vector Fields Method
Ever-increasing environmental regulations and competition within industry to create the best performing, most cost-effective product has driven the development of computational design, analysis and optimization tools. Many ... -
Page or Stage: Reading Shakespeare Comics as Performance
While previous scholarship concerning Shakespeare comics has considered their pedagogical function as teaching tools to make Shakespeare more accessible or their role in preserving Shakespeare’s place within the popular ... -
Pain after cesarean: a pilot study assessing pain and health-related quality of life in women after cesarean section
(2007-10-01)Purpose: This thesis addresses feasibility issues of conducting a descriptive study of pain and health-related quality of life (HRQOL) in women after Cesarean section (c-section). Objectives: Feasibility issues surrounding ... -
Pain Communication in Ethnically Concordant and Discordant Dyads
(2011-05-30)While ethnicity is often regarded as a factor in pain experience and expression, ethnic pain research has almost exclusively focused on the intrapersonal dimension of the pain experience and failed to recognize the complex ... -
Painting a Portrait of Organizational Evaluation Capacity in the Canadian Art Museum sector
Not only is research on program evaluation practice and capacity in art museums largely absent, but also the actual dimensions of evaluation capacity as they could be observed in these unique professional settings have ... -
Pairwise Optimization of Modulation Constellations for Non-Uniform Sources
(2009-10-07)The design of two-dimensional signal constellations for the transmission of binary non-uniform memoryless sources over additive white Gaussian noise channels is investigated. The main application of this problem is the ... -
Paleoclimatic and instrumental records of environmental variability in northeastern North America
(2008-12-18)Clastic varves and tree-rings offer unique opportunities to decipher various changing paleoclimatic and environmental conditions through the past. The environmental signals they contain can differ greatly from one proxy ... -
Paleoecological Reconstruction of the Holocene Fire Regime at Mud Lake, Eastern Ontario, near St. Lawrence Islands National Park
(2010-02-01)Wildfire is an ecological disturbance that plays an important role in ecosystem function and interacts with climate and vegetation, relationships that may be altered by ongoing climate change. Insights from paleoecology ... -
Paleoecology, Diagenesis and Biological Affinity of Tetradiids in the Upper Ordovician (Sandbian) Black River Group of the Kingston Area, Ontario, Canada
(2016-06-14)Tetradiids are a group of colonial, tubular fossils that occur globally in Middle to Upper Ordovician strata. Tetradiids were first described as a type of tabulate coral; however, based on their four-fold symmetry, division, ... -
A Paleolimnological and Modeling Investigation of Water Quality and Biological Changes in Algonquin Park Lakes in Response to Multiple Stressors
Algonquin Park (herein called the “Park”) is one of only two parks in Ontario that allows private cottages, with the first leases offered in 1905. In total, 22 lakes in the Park have a total of 303 cottage lots in their ... -
Paleolimnological Assessment of Algal Production During the Holocene Thermal Maximum from the Sediment Record of a Boreal Lake in Northeastern Ontario
The Holocene Thermal Maximum (HTM) was a period of enhanced warmth during the early-to- mid Holocene period largely caused by enhanced solar insolation. In northwestern Ontario, the HTM was characterized by a lower abundance ... -
Paleolimnological assessment of environmental changes occurring on Pim Island, Nunavut, High Arctic Canada
(2010-12-23)Despite the documented sensitivity of polar environments, long-term monitoring data are especially sparse in these regions. Diatom-based paleolimnology has contributed significantly to understanding the response of Arctic ... -
A Paleolimnological Assessment of Eutrophication Trends in the St. Lawrence River Area of Concern Over the Past 70 Years
Recent surface-water surveys suggest that high nutrient concentrations and nuisance algae remain an issue in the St. Lawrence River Area of Concern (AOC) at Cornwall, Ontario, particularly in the tributaries and nearshore ... -
Paleolimnological assessment of Holocene climatic and environmental change in two lakes located in different regions of the Canadian Arctic tundra
(2008-11-12)Paleoclimatic research in the Canadian Arctic has increased in recent decades; however, there is still much to learn about the nature and extent of past climate change in this vast, environmentally sensitive region. This ... -
A paleolimnological assessment of recent environmental changes in lakes of the western Canadian Arctic
(2013-04-17)The freshwater ecosystems in the western Canadian Arctic are threatened by multiple and interacting stressors, as high-latitude regions are undergoing rapid change resulting from climate warming and other human-related ... -
A Paleolimnological Examination of Cladoceran (Branchiopoda, Crustacea) Assemblages in Softwater Nova Scotia (Canada) Lakes and Their Responses to Multiple Stressors
(2012-08-22)The Canadian province of Nova Scotia has an abundance of lakes impacted by multiple stressors, including acidification, lakewater calcium (Ca) decline, climate change, and fish introductions. In spite of this, little is ...