Browsing Graduate Theses, Dissertations and Projects by Author "Cahill, Catherine M."
Now showing items 1-10 of 10
-
Attenuation of morphine tolerance, reward, and spinal gliosis in neuropathic pain by ultra-low dose alpha2-adrenergic antagonists
Grenier, Patrick (2016-04-28)Aims: To determine the effects of ULD α2-AR antagonists on: i) sensory responses in morphine tolerant and nerve injured rats, ii) chronic morphine and nerve-injury induced spinal gliosis and neuronal activation, iii) ... -
Functional and molecular approaches to study mu and delta opioid receptor hetero-oligomerization in a model of neuropathic pain
Sutherland, Karen (2009-09-24)Neuropathic (NP) pain is a debilitating form of chronic pain that can result from a variety of disease states that target the sensory nervous system. NP pain can manifest as burning or shooting pain, and is commonly ... -
Functional Magnetic Resonance Imaging of Pain in the Spinal Cord and Brainstem
Foad Ghazni, Niousha (2008-09-26)Functional magnetic resonance imaging (fMRI) studies performed to date have focused on brain structures rostral to the thalamus, although the first level of sensory information and pain transmission occurs at the spinal ... -
Functional Magnetic Resonance Imaging of Peripheral Neuropathic Pain in the Spinal Cord and Brainstem
Leitch, Jordan Kelly (2010-08-06)To date, most studies investigating the neural signature of pain in humans have focused on the brain, and those studies concerned with more caudal areas (such as the spinal cord (SC) or brainstem) have used only experimental ... -
HEME-OXYGENASE INHIBITORS: A NOVEL STRATEGY FOR TREATING CHRONIC AND PERSISTENT PAIN
Philbrook, Michael J. P. (2015-12-16)It is well recognized that there is a lack of effective therapies for treating chronic pain. Therefore, development of novel analgesics with minimal side effects and the absence of addiction potential are essential. The ... -
INVESTIGATING THE EFFECTS OF PERIPHERAL NERVE INJURY ON δ OPIOID RECEPTOR EXPRESSION AND FUNCTION: IMPLICATIONS FOR THE TREATMENT OF CHRONIC NEUROPATHIC PAIN
Holdridge, Sarah (2009-04-22)Neuropathic (NP) pain is a debilitating chronic pain disorder that is a challenge to diagnose and an even greater challenge to treat. Commonly described as burning or shock-like, NP pain is characteristically resistant to ... -
Investigating the Effects of Prolonged Mu Opioid Receptor Activation Upon Opioid Receptor Heteromerization
Ong, EdmundOpioid receptors are the sites of action for morphine and most other clinically-used opioid drugs. Abundant evidence now demonstrates that different opioid receptor types can physically associate to form heteromers. Owing ... -
The Molecular and Behavioural Effects of Glial Modulators Propentofylline and PJ34 in a Rodent Model of Neuropathic Pain
Grenier, Patrick (2010-08-31)Neuronal-glial interactions play an important role in the development of neuropathic (NP) pain states. Earlier studies in our laboratory suggest a role for activated glia in morphine-induced delta opioid receptor (DOR) ... -
Nuclei-Specific Response to Pain in the Bed Nucleus of the Stria Terminalis
Morano, Tania J. (2007-10-01)The bed nucleus of the stria terminalis (BST) is a basal forebrain cluster of several distinct nuclei. It has been proposed that the BST coordinates autonomic, neuroendocrine, and behavioral functions through the integration ... -
OPIOIDS AND GLIA: INVESTIGATING THE MECHANISMS THROUGH WHICH ULTRA-LOW DOSE OPIOID ANTAGONISTS MODULATE OPIOID TOLERANCE AND HYPERALGESIA.
Mattioli, Theresa Alexandra (2013-04-25)Ultra-low doses (ULD) of the opioid receptor antagonists, naloxone and naltrexone, augment the analgesic actions of morphine, block the induction of tolerance, and reverse established tolerance by an unknown mechanism. ...