Browsing Graduate Theses, Dissertations and Projects by Author "Rafferty, Steven"

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Investigating the Interactions Between the Thiolate Ligand and Mutants of a Conserved Tryptophan in the Proximal Heme Pocket of the Oxygenase Domains of Endothelial and Staphyloccus Aureus Nitric Oxide Synthases

Driscoll, Danelle Rae (2008-09-04)

The electronegativity of thiolate ligation in the hemeprotein nitric oxide synthase (NOS) proteins has been identified as an influence on autoinhibition in this enzyme. The mutation of a conserved tryptophan residue, which ...
Investigating the stability of nitric oxide synthase quaternary structure to denaturant and temperature

Hucaluk, Cristen Anne (2007-10-30)

A limitation to investigations of homodimeric protein dissociation is that the signals produced from methods such as fluorescence and circular dichroism represent both dissociation and protein unfolding that may be occurring ...