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Novel Rac1/Stat3 and Stat5 Pathway in Differentiation and Neoplastic Transformation of Breast Epithelial Cells: Potential Prognostic Markers
(2014-01-03)
Breast cancer is one of the leading causes of death of women in North America. Signal Transducer and Activator of Transcription (Stat)3 and Stat5 are transcription factors involved in normal breast development, and are ...
Vitamin D and mammographic density in postmenopausal women: A cohort study nested within a chemoprevention trial
(2014-03-31)
Background: Vitamin D may be important in the causal pathway to breast cancer (BC) by influencing mammographic breast density (MD). However, previous study results in postmenopausal women are inconsistent. Study objectives ...
Validation of a Gene-Expression Based Assay for BRCA1 Function
(2013-09-26)
Breast cancer is a disease that afflicts a significant proportion of women globally. 5-10% of breast cancer cases are linked to inherited polymorphisms in critical genes such as BRCA1, a tumour suppressor essential for ...
Mapping the risk of breast cancer to exposure from traffic-related air pollution using land-use regression in Vancouver, BC
(2015-03-02)
An environmental role in breast cancer etiology has been suspected but evidence is still inconclusive. Traffic-related air pollution is a potentially modifiable risk factor that has been studied in the etiology of breast ...
Selective serotonin reuptake inhibitors (SSRIs) and breast cancer : a record linkage study
(2008-01-09)
Evidence suggests that selective serotonin reuptake inhibitors (SSRIs, a class of antidepressant medications) may contribute to increased breast cancer risk by stimulating the secretion of prolactin, a potential tumour ...
Molecular Stress Signaling in Breast Epithelial Cells
(2008-01-15)
Breast cancer is a complex disease, whose etiology is not well understood. A number of factors have been found to contribute to its development. Psychological stress has been recognized as such a factor in epidemiological ...
Established and suspected risk factors for breast cancer: A case-control study in Vancouver, BC and Kingston, ON
(2011-08-15)
More than half of all cases of breast cancer occur among women without any known risk factors. More research is needed on suspected risk factors in order to refine current breast cancer screening tools. The objectives ...
Melatonin and sex hormones among rotating shift nurses
(2010-09-15)
Background: In 2007, the International Agency for Research on Cancer classified shift-work involving circadian disruption as a “probable carcinogen.” One proposed pathway for this relationship involves nighttime light ...
Immobilization and Catheter Guidance for Breast Brachytherapy Using Patient-Specific Templates
(2011-10-03)
Brachytherapy is an important method of breast cancer treatment; however, improvements in both treatment planning and delivery are needed. The procedure involves insertion of catheters in the tumor site, which, in current ...
Characterization of Glucocorticoid Receptor Promoter Methylation in Breast Cancer
(2012-09-26)
Epidemiological studies have identified psychological stress as a significant risk factor in breast cancer. The stress response is regulated by the HPA axis in the brain and is mediated by glucocorticoid receptor (GR) ...