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Melatonin and sex hormones among rotating shift nurses
(2010-09-15)
Background: In 2007, the International Agency for Research on Cancer classified shift-work involving circadian disruption as a “probable carcinogen.” One proposed pathway for this relationship involves nighttime light ...
Selective serotonin reuptake inhibitors (SSRIs) and breast cancer : a record linkage study
(2008-01-09)
Evidence suggests that selective serotonin reuptake inhibitors (SSRIs, a class of antidepressant medications) may contribute to increased breast cancer risk by stimulating the secretion of prolactin, a potential tumour ...
Communicating Results of New Genomic Tests to Physicians
(2009-05-07)
Background: New genomic tests are being developed to predict an individual’s risk of cancer recurrence by analyzing the expression of multiple genes. However, it is unclear how to report the test results so that they would ...
Lost in Translation? Russian Media Portrayals and Laypersons’ Interpretations of Angelina Jolie’s Breast Cancer Discourse
(2016-05-24)
In May 2013, Angelina Jolie revealed that because she had a family history of breast and ovarian cancer and carried a rare BRCA gene mutation, she had undergone a preventive double mastectomy. Media coverage has been ...
The role of vitamin D signalling in the interaction between mesenchymal mammary tumour cells and macrophages
(2016-09-01)
The transition of epithelial-like tumour cells to those exhibiting mesenchymal characteristics (Epithelial-to-mesenchymal Transition; EMT) is an integral process in breast cancer metastasis. EMT can be promoted by Transforming ...
Characterization of Glucocorticoid Receptor Promoter Methylation in Breast Cancer
(2012-09-26)
Epidemiological studies have identified psychological stress as a significant risk factor in breast cancer. The stress response is regulated by the HPA axis in the brain and is mediated by glucocorticoid receptor (GR) ...
Novel Rac1/Stat3 and Stat5 Pathway in Differentiation and Neoplastic Transformation of Breast Epithelial Cells: Potential Prognostic Markers
(2014-01-03)
Breast cancer is one of the leading causes of death of women in North America. Signal Transducer and Activator of Transcription (Stat)3 and Stat5 are transcription factors involved in normal breast development, and are ...
Targeting the actin cytoskeleton in HER2+ metastatic cancer cells using a macrolide toxin
(2016-10-03)
Breast and ovarian cancers are among the leading causes of cancer related deaths in women worldwide. In a subset of these cancers, dysregulation of the human epidermal growth factor receptor 2 (HER2) leads to overexpression ...
The Role of Endocytic Adaptor Endophilin A2 in Human Breast Cancer Signaling, Metastasis, and Targeted Therapy
The leading cause of death in breast cancer is metastatic burden. Classification of breast cancer cases by molecular subtype reveals that those categorized as triple-negative (TNBC) and human epidermal growth factor receptor ...
Immobilization and Catheter Guidance for Breast Brachytherapy Using Patient-Specific Templates
(2011-10-03)
Brachytherapy is an important method of breast cancer treatment; however, improvements in both treatment planning and delivery are needed. The procedure involves insertion of catheters in the tumor site, which, in current ...