Search
Now showing items 1-10 of 44
Melatonin and sex hormones among rotating shift nurses
(2010-09-15)
Background: In 2007, the International Agency for Research on Cancer classified shift-work involving circadian disruption as a “probable carcinogen.” One proposed pathway for this relationship involves nighttime light ...
Selective serotonin reuptake inhibitors (SSRIs) and breast cancer : a record linkage study
(2008-01-09)
Evidence suggests that selective serotonin reuptake inhibitors (SSRIs, a class of antidepressant medications) may contribute to increased breast cancer risk by stimulating the secretion of prolactin, a potential tumour ...
COMBINING BIOMARKERS AND CLINICOPATHOLOGIC FACTORS FOR PREDICTION OF RESPONSE TO ADJUVANT CHEMOTHERAPY FOR BREAST CANCER: COX MODEL AND SUPPORT VECTOR MACHINE (SVM) METHODS
(2010-04-27)
Background: Breast cancer is a complex disease, both phenotypically and etiologically. Accordingly, the responses to various treatments in the adjuvant setting among individuals vary considerably. There is a demand for ...
Communicating Results of New Genomic Tests to Physicians
(2009-05-07)
Background: New genomic tests are being developed to predict an individual’s risk of cancer recurrence by analyzing the expression of multiple genes. However, it is unclear how to report the test results so that they would ...
Lost in Translation? Russian Media Portrayals and Laypersons’ Interpretations of Angelina Jolie’s Breast Cancer Discourse
(2016-05-24)
In May 2013, Angelina Jolie revealed that because she had a family history of breast and ovarian cancer and carried a rare BRCA gene mutation, she had undergone a preventive double mastectomy. Media coverage has been ...
The role of vitamin D signalling in the interaction between mesenchymal mammary tumour cells and macrophages
(2016-09-01)
The transition of epithelial-like tumour cells to those exhibiting mesenchymal characteristics (Epithelial-to-mesenchymal Transition; EMT) is an integral process in breast cancer metastasis. EMT can be promoted by Transforming ...
GLUCOCORTICOID RECEPTOR (NR3C1) PROMOTER METHYLATION AS A CIRCULATING BREAST CANCER BIOMARKER AND ITS ROLE IN TAMOXIFEN SENSITIVITY
(2014-09-15)
The glucocorticoid receptor (GR) binds glucocorticoids and transcriptionally regulates genes involved in immune response, cellular proliferation, and apoptosis. Previous work in our lab using MeDIP followed by qPCR found ...
Characterization of Glucocorticoid Receptor Promoter Methylation in Breast Cancer
(2012-09-26)
Epidemiological studies have identified psychological stress as a significant risk factor in breast cancer. The stress response is regulated by the HPA axis in the brain and is mediated by glucocorticoid receptor (GR) ...
GLUCOCORTICOID RECEPTOR FUNCTION AND ITS ROLE IN TAMOXIFEN RESISTANCE
(2015-09-26)
The function of the glucocorticoid receptor (GR) is crucial for the development and proliferation of normal human breast cells. The primary activity of GR is in its binding to glucocorticoids and the subsequent activation ...
THE UNLIGANDED GLUCOCORTICOID RECEPTOR AS A TRANSCRIPTIONAL REGULATOR IN MAMMARY EPITHELIAL CELLS
(2012-12-03)
This work presents the first evidence of a ligand-independent role for the glucocorticoid receptor (GR) as a positive regulator of gene expression in mammary cells. We have demonstrated that unliganded GR interacts directly ...