TAZ (Transcriptional co-activator with PDZ-binding motif) is a WW-domain containing protein recently identified as a downstream component of the Hippo tumor suppressor pathway and mediator of biologically important processes ...

This work presents the first evidence of a ligand-independent role for the glucocorticoid receptor (GR) as a positive regulator of gene expression in mammary cells. We have demonstrated that unliganded GR interacts directly ...

Background: Moderate-to-vigourous intensity physical activity (MVPA) is among the few modifiable factors known to reduce breast cancer risk. However, the independent effects of leisure-time, household, and occupational ...

Background: The Mammary Prevention.3 (MAP.3) randomized placebo-controlled trial evaluating exemestane for breast cancer prevention demonstrated a 65% relative reduction in invasive breast cancer incidence. Up to 50% of ...

Background: In 2007, the International Agency for Research on Cancer classified shift-work involving circadian disruption as a “probable carcinogen.” One proposed pathway for this relationship involves nighttime light ...

Evidence suggests that selective serotonin reuptake inhibitors (SSRIs, a class of antidepressant medications) may contribute to increased breast cancer risk by stimulating the secretion of prolactin, a potential tumour ...

Background: Breast cancer is a complex disease, both phenotypically and etiologically. Accordingly, the responses to various treatments in the adjuvant setting among individuals vary considerably. There is a demand for ...

Decreased expression of the tumor suppressor gene BRCA1 (breast cancer 1, early onset) is frequently observed in sporadic breast tumors, with the decrease not attributed to mutations or hypermethylation of the promoter. A ...

Brachytherapy is an important method of breast cancer treatment; however, improvements in both treatment planning and delivery are needed. The procedure involves insertion of catheters in the tumor site, which, in current ...

Epidemiological studies have identified psychological stress as a significant risk factor in breast cancer. The stress response is regulated by the HPA axis in the brain and is mediated by glucocorticoid receptor (GR) ...