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NOVEL AZOLE-BASED HEME OXYGENASE INHIBITORS: IN VIVO CHARACTERIZATION AND THERAPEUTIC APPLICATION IN CANCER
Heme degradation is catalyzed through the action of heme oxygenases (HO), present as inducible (HO-1) and constitutive (HO-2) isoforms, resulting in the endogenous production of carbon monoxide (CO), biliverdin and iron. ...
Impacts of Placental Growth Factor Deficiency and of Preeclampsia on Brain Development and Function
Preeclampsia (PE) is a significant gestational disorder affecting 3-5% of all human pregnancies. In many PE pregnancies, maternal plasma is low in the placentally-produced angiokine “placental growth factor” (PGF). Offspring ...
Characterizing angiodysplasia in type 2 von Willebrand disease (VWD) using blood outgrowth endothelial cells (BOECs)
Gastrointestinal bleeding associated with angiodysplasia is a common, often intractable complication in patients with von Willebrand disease (VWD). von Willebrand factor (VWF), the protein deficient in VWD, was recently ...