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GLUCOCORTICOID RECEPTOR (NR3C1) PROMOTER METHYLATION AS A CIRCULATING BREAST CANCER BIOMARKER AND ITS ROLE IN TAMOXIFEN SENSITIVITY
The glucocorticoid receptor (GR) binds glucocorticoids and transcriptionally regulates genes involved in immune response, cellular proliferation, and apoptosis. Previous work in our lab using MeDIP followed by qPCR found ...
Characterization of Glucocorticoid Receptor Promoter Methylation in Breast Cancer
Epidemiological studies have identified psychological stress as a significant risk factor in breast cancer. The stress response is regulated by the HPA axis in the brain and is mediated by glucocorticoid receptor (GR) ...