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Regulatory Domains of the Human Calpain Family
Calpains are intracellular enzymes that merge cysteine protease and calcium sensing activities together in one molecule. They respond to Ca2+ signals and modify the activity of their targets by selective proteolysis. ...
Calcium Influx and Release Controls Neuroendocrine Cell Secretion and Excitability
Ca2+ dynamics affect many critical cellular processes. In the bag cell neurons of Aplysia californica, intracellular Ca2+ is elevated during a prolonged period of firing known as the afterdischarge. This consists of a fast ...
The Calmodulin-Like Protein CML42 is Involved in Trichome Branching in Arabidopsis
The Snedden lab has been studying a family of Ca2+-binding proteins from Arabidopsis that are related to the prototypical Ca2+ sensor calmodulin (CaM) and are termed CMLs (CaM-like proteins). Previous work on CML42 ...
The Activation of Persistent Inward Currents in Feline Spinal Motoneurons is Noise and Location-Dependent
The ability to control the output for a given input is an important feature of neurons as it allows them to respond to a multitude of inputs via the production of a scalable output. Using compartmental models of morphologically ...