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Identification and characterization of ΔNp63 as a novel transcriptional target negatively regulated by TAZ in mammary tumorigenesis
The transcriptional co-activator with PDZ-binding domain (TAZ) is a key downstream component of the Hippo pathway that plays important roles in animal size control, stem cell renewal, differentiation and tumorigenesis. We ...
NOVEL AZOLE-BASED HEME OXYGENASE INHIBITORS: IN VIVO CHARACTERIZATION AND THERAPEUTIC APPLICATION IN CANCER
Heme degradation is catalyzed through the action of heme oxygenases (HO), present as inducible (HO-1) and constitutive (HO-2) isoforms, resulting in the endogenous production of carbon monoxide (CO), biliverdin and iron. ...
Melatonin Patterns Among Female Hospital Employees On Day And Night Shifts: Assessment By Different Exposure Metrics
Objective: To assess the associations of different shift work exposure metrics with circadian melatonin mesor, amplitude and acrophase. Methods: In a cross-sectional study of 328 female hospital personnel working ...