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Identification and characterization of ΔNp63 as a novel transcriptional target negatively regulated by TAZ in mammary tumorigenesis
The transcriptional co-activator with PDZ-binding domain (TAZ) is a key downstream component of the Hippo pathway that plays important roles in animal size control, stem cell renewal, differentiation and tumorigenesis. We ...
Melatonin Patterns Among Female Hospital Employees On Day And Night Shifts: Assessment By Different Exposure Metrics
Objective: To assess the associations of different shift work exposure metrics with circadian melatonin mesor, amplitude and acrophase. Methods: In a cross-sectional study of 328 female hospital personnel working ...
Novel Azole-Based Heme Oxygenase Inhibitors: In Vivo Characterization and Therapeutic Application in Cancer
Heme degradation is catalyzed through the action of heme oxygenases (HO), present as inducible (HO-1) and constitutive (HO-2) isoforms, resulting in the endogenous production of carbon monoxide (CO), biliverdin and iron. ...