Now showing items 1-2 of 2
Validation of a Gene-Expression Based Assay for BRCA1 Function
Breast cancer is a disease that afflicts a significant proportion of women globally. 5-10% of breast cancer cases are linked to inherited polymorphisms in critical genes such as BRCA1, a tumour suppressor essential for ...
Characterization of Variants of Unknown Significance (VUS) in BRCA1
Approximately 3%-8% of breast cancer patients carry one defective BRCA1 or BRCA2 allele. While the rise of genetic testing have helped identify BRCA mutation carriers, the implication of certain mutations are still unknown. ...