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Glucosamine May Reduce Pain in Individuals with Knee Osteoarthritis
Clinical Question: Does treatment with oral glucosamine reduce the progression of joint structure and symptoms in people with knee osteoarthritis? Clinical Bottom Line: The effectiveness of oral glucosamine in reducing the progression of joint space narrowing has not yet been definitively established due to the small numbers of long term clinical trials and weak statistical evidence. However, the evidence from these studies suggests that oral glucosamine is effective in reducing symptomatic pain in subjects with knee osteoarthritis.