Pathology and Molecular Medicine, Department of
The Department of Pathology and Molecular Medicine is home to many vibrant research programs with focused areas of excellence including cancer biology and molecular hemostasis.
This community includes research outputs produced by faculty and students. Submitting works to QSpace may enable compliance with the Tri-Agency Open Access Policy on Publications.
When you submit your work to QSpace, you retain copyright and grant the Library a non-exclusive license to distribute and preserve. Works are open access unless restricted by the creator.
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Recent Submissions
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Identification of Novel Small Molecule Inhibitors (SMI) of YAP/TAZ Oncoproteins in Breast Cancer Using HiBiT Bioluminescent Biosensors
Breast cancer (BC) is the most frequently diagnosed cancer among females, accounting for 25% of all cancer cases worldwide. Among all the subtypes of BC, triple negative breast cancer (TNBC) is considered one of the ... -
The Effects of TET2-Deficiency on Neutrophil Gene Expression and Function
Background: Clonal hematopoiesis of indeterminate potential (CHIP), a potential precursor to myelodysplastic syndrome (MDS), affects over 10% of adults over 65. Loss-of-function ten-eleven-translocation methylcytosine ... -
The Role of von Willebrand Factor in the Pathogenesis of Deep Vein Thrombosis in Acute Inflammation
Venous thromboembolism, comprised of deep vein thrombosis (DVT) and pulmonary embolism, is a thrombotic cardiovascular disease that accounts for a significant portion of the global health burden. Among its risk factors, ... -
Identification and Characterization of Novel Kinases Regulating Programmed Death Ligand-1 (PD-L1) in Immune Evasion of Triple Negative Breast Cancer Cells
The programmed death ligand-1 (PD-L1) is an immune checkpoint protein expressed on a variety of antigen-presenting cells to normalize immune system. Recently, overexpression of PD-L1 on the surface of cancer cells has been ... -
Elucidating Isoform Specific Roles of Calpain-1 and Calpain-2 in Breast Cancer
Breast cancer is the most frequently diagnosed women’s cancer in Canada. Average patient survival rates are high, but they are significantly reduced for those patients whose cancer reaches stage IV – metastatic disease. ... -
Regulation of the Glucocorticoid Receptor Promoter and Its Prognostic Value in Tamoxifen-Treated ER+ Breast Cancer
Most breast cancers are estrogen receptor positive (ER+) and therefore benefit from endocrine-based therapies such as tamoxifen which impair estrogen signaling. However, resistance is a major clinical concern and ER status ... -
Comprehensive analysis of the Ontario eligibility criteria for Hereditary Breast and Ovarian Cancer Syndrome
Germline mutations in breast and ovarian cancer are rare, with approximately 10% and 13% being hereditary in origin, respectively. In 2001, the Ontario Ministry of Health and Long Term Care (MOHLTC), in an effort to contain ... -
Evaluation of the hemostatic stress response in Type 1 von Willebrand Disease
Type 1 von Willebrand Disease (VWD) is an inherited bleeding disorder resulting from a quantitative deficiency in the procoagulant protein von Willebrand factor (VWF). Diagnosis is dependent on a reduction in VWF levels ... -
Identification of Novel Receptor Tyrosine Kinases Regulating the Hippo Pathway in Cancer Cells
Several studies have shown that the Hippo pathway plays an important role in tissue growth, organ size control, and cell death. Deregulation of the Hippo pathway contributes to loss of cell contact inhibition and continuing ... -
The role of von Willebrand factor in the pathogenesis of immunothrombosis
Pathologic immunothrombosis is the formation of arterial, venous or microvascular thrombi in response to dysregulated activation of the immune system. Inflammatory diseases such as sepsis and obesity are associated with a ... -
Evaluating the relationship between the RET receptor tyrosine kinase and TMEM127
Pheochromocytomas (PCC) are highly heritable neoplasms of the adrenal gland, carrying germline mutations in approximately 40% of cases. PCC susceptibility genes have been subdivided into two clusters: hypoxia-related genes, ... -
The scavenger receptor SCARA5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen
(Wiley, 2019-05-24)Background Scavenger receptors play a significant role in clearing aged proteins from the plasma, including the large glycoprotein coagulation factors von Willebrand factor (VWF) and factor VIII (FVIII). A large genome-wide ... -
Impact of Androgen Deprivation Therapy on the Gastrointestinal Microbiota of Prostate Cancer Patients
Background: Prostate Cancer (PCa) is one of the leading causes of cancer in men. Androgen deprivation therapy (ADT), the standard of care for advanced PCa, has been associated with developing the metabolic syndrome. The ... -
Exploring the Genomic Binding Landscape of the Oncogenic Transcription Factor TCF3-PBX1 in Acute Lymphoblastic Leukemia
Treatment of acute lymphoblastic leukemia (ALL) has become quite effective over the last two decades. However, further progress is limited by a lack of understanding of the biological processes that drive this disease. ... -
The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF-dependent and independent manner
(2019-02-11)Essentials CLEC4M is an endocytic receptor for factor FVIII. CLEC4M interacts with FVIII in a VWF-dependent and independent manner. CLEC4M binds to mannose-containing glycans on FVIII. CLEC4M internalization of FVIII ... -
The role of PPARg-dependent microRNA expression during breast tumour metastasis
Previous studies by Dr. Nicol showed the first direct in vivo evidence that peroxisome proliferator-activated receptor (PPAR)γ normally suppresses environmental chemical 7,12-dimethylbenz[a]anthracene (DMBA)-mediated breast ... -
Differential Contributions of RET-isoforms to Tumour Invasion
RET is a receptor tyrosine kinase (RTK) which is normally activated at the cell surface by glial cell line-derived neurotrophic factors and plays critical roles during embryogenesis. RET is expressed as two protein isoforms, ... -
Novel Methods of Factor VIII Tolerance Induction in Hemophilia A Mouse Models
The most serious complication of factor VIII (FVIII) replacement therapy in hemophilia A (HA) patients remains the development of anti-FVIII antibodies (inhibitors). At this time, there are no methods to prevent inhibitor ... -
Diagnostic and Prognostic Biomarkers for Early Prostate Cancer
Prostate cancer is diagnosed and treated primarily on the basis of histopathological assessment of biopsies and cancer extent. Unfortunately, this assessment, performed by pathologists on very small amounts of biopsy tissue, ... -
Characterizing the Role of the RET Receptor Tyrosine Kinase in Colorectal Cancer
RET is a receptor tyrosine kinase (RTK) that plays important roles in both normal development and cancer. RET has well-established oncogenic roles in thyroid cancer and growing evidence implicates RET activity in the ...
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