Pathology and Molecular Medicine, Department of
The Department of Pathology and Molecular Medicine is home to many vibrant research programs with focused areas of excellence including cancer biology and molecular hemostasis.
This community includes research outputs produced by faculty and students. Submitting works to QSpace may enable compliance with the Tri-Agency Open Access Policy on Publications.
When you submit your work to QSpace, you retain copyright and grant the Library a non-exclusive license to distribute and preserve. Works are open access unless restricted by the creator.
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Recent Submissions
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ROLE OF THE CADHERIN-11/RAC1/STAT3 AXIS IN SRC-MEDIATED TRANSFORMATION AND IN ADIPOCYTIC DIFFERENTIATION
Stat3 (signal transducer and activator of transcription-3) is activated by phosphorylation on tyrosine-705 (Stat3-ptyr705) downstream of cytokines, growth factors, and oncogenes. Our lab has demonstrated that engagement ... -
Delineating Novel Genetic and MicroRNA Regulatory Mechanisms in Aggressive Subtypes of Breast Cancer
Breast cancer will be diagnosed in over 26,500 Canadians this year. Despite advances, identifying who will develop aggressive breast tumours or who will respond to treatment remains a clinical challenge. This dissertation ... -
The regions connecting the membrane spanning and nucleotide binding domains of MRP1 are functionally distinct
Multidrug resistance protein 1 (MRP1) is a 190 kDa ATP-binding cassette transporter which effluxes xeno- and endobiotic organic anions including estradiol glucuronide (E217βG) and the pro-inflammatory leukotriene C4 (LTC4). ... -
Evaluating the pre-B-cell receptor as a potential mediator of leukemogenesis downstream of the TCF3-PBX1 oncogenic transcription factor
Approximately 5% of B-progenitor acute lymphoblastic leukemia (B-ALL) harbor a somatic 1;19 chromosomal translocation which generates a fusion gene coding for TCF3-PBX1. Recent studies have shown that leukemic progenitors ... -
Calpain-1 and Calpain-2 Promote HER2/NEU Tumorigenesis and Independently Promote Metastasis in Triple Negative Breast Cancer
Calpains are a family of calcium activated cysteine proteases. Calpain-1 and calpain-2 are obligate heterodimers composed of isoform specific catalytic subunits (encoded by capn1 and capn2, respectively) coupled with the ... -
The role of extracellular vesicles in the transfer of multidrug resistance in human ovarian cancer cells
Ovarian cancer is the fifth most common cancer in Canadian women and has the highest mortality rate of all gynecologic malignancies. First-line treatment is typically cytoreductive surgery followed by a combination of ... -
Metabolic features of prostate malignancy
Altered metabolism is an inherent property of cancer and provides a rich opportunity for exploring its underlying biology and developing diagnostic biomarkers. We used desorption electrospray ionization mass spectrometry ... -
Identification and characterization of transcriptional targets of TAZ in human breast cancer
TAZ is a transcriptional co-activator and an effector of the Hippo signaling pathway. Since its discovery in 2000, we have gained tremendous insights into the roles TAZ plays in development and disease. TAZ acts as an ... -
Identification of Novel Proteins Interacting with LATS1/2 During Tumorigenesis and Anti-Tubulin Drug Response
The Hippo pathway is a signaling cascade that plays essential roles in organisms such as development, organ size control, stem cell differentiation and renewal, as well as important processes necessary for cancer development ... -
Differential Trafficking of RET Receptor Tyrosine Kinase Isoforms
The RET receptor tyrosine kinase is implicated in both normal development and cancer. RET is expressed as two protein isoforms, RET9 and RET51, which differ in the number of their C-terminal amino acids. RET isoforms are ... -
Evaluation of the determinants and characterization of bleeding in hemophilia A and B carriers
Hemophilia A and B are bleeding disorders caused by a deficiency in coagulation factor VIII (FVIII) or coagulation factor IX (FIX), respectively. Due to the X-linked inheritance pattern, males are affected with the disease, ... -
Early mechanisms of factor VIII immunity in hemophilia A
The most serious complication in treating hemophilia A (HA) is the development of an immune response to the therapeutically-administered factor VIII (FVIII). A better understanding of initiating events leading to FVIII ... -
The Role of TET2 in Macrophage Differentiation and Polarization
The epigenetic regulator Tet methylcytosine dioxygenase 2 (TET2) catalyzes the conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), leading to DNA demethylation. Inactivating TET2 mutations are common ... -
Regulation of HC11 Mouse Mammary Epithelial Cell Differentiation by the Rac/Stat3 axis
Studying cellular differentiation can reveal valuable information underlying the mechanisms that mediate cell fate. The HC11 mouse mammary epithelial cell line has long been used as a model to study lactogenic differentiation ... -
Roles of the Immune Cytokine Environment on Clonal Growth of Murine and Human Tet2 Mutant Bone Marrow Progenitors: Implications for Myelodysplastic Syndromes
TET2 is a tumor suppressor gene that has been implicated in the epigenetic regulation of gene expression. Inactivating TET2 mutations are common in MDS. These mutations may contribute to early clonal dominance and myeloid ... -
Kinome-wide CRISPR-Cas9 screen to identify kinases involved in Taxol resistance in breast cancer
(2016-08-31)Breast cancer is the most frequently diagnosed cancer in women, accounting for over 25% of cancer diagnoses and 13% of cancer-related deaths in Canadian women. There are many types of therapies for treatment or management ... -
Characterization of ALDH1A1 as a novel tumorigenic target mediating TAZ-induced lung tumorigenesis and stem cell phenotypes
(2016-08-24)Recent studies suggest that lung cancer stem cells (CSCs) may play major roles in lung cancer development, metastasis and drug resistance. Therefore, identification of lung CSC drivers may provide promising targets for ... -
Investigating the Role of cAMP-Signaling in the Regulation of Vascular Endothelial Cell Adaptive Responses to Fluid Shear Stress
(2016-05-11)The circulating blood exerts a force on the vascular endothelium, termed fluid shear stress (FSS), which directly impacts numerous vascular endothelial cell (VEC) functions. For example, high rates of linear and undisturbed ... -
The effect of biomechanical and biochemical regulators on the expression of Factor VIII and von Willebrand Factor in endothelial cells
(2016-01-29)The coagulant protein Factor VIII (FVIII) has been the subject of much debate and controversy regarding where, when, and how it is expressed and produced in the human body for much of the past 30-40 years. Expression was ...
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