Pathology and Molecular Medicine, Department of
The Department of Pathology and Molecular Medicine is home to many vibrant research programs with focused areas of excellence including cancer biology and molecular hemostasis.
This community includes research outputs produced by faculty and students. Submitting works to QSpace may enable compliance with the Tri-Agency Open Access Policy on Publications.
When you submit your work to QSpace, you retain copyright and grant the Library a non-exclusive license to distribute and preserve. Works are open access unless restricted by the creator.
Collections in this community
Recent Submissions
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Identification of Novel Proteins Interacting with LATS1/2 During Tumorigenesis and Anti-Tubulin Drug Response
The Hippo pathway is a signaling cascade that plays essential roles in organisms such as development, organ size control, stem cell differentiation and renewal, as well as important processes necessary for cancer development ... -
Differential Trafficking of RET Receptor Tyrosine Kinase Isoforms
The RET receptor tyrosine kinase is implicated in both normal development and cancer. RET is expressed as two protein isoforms, RET9 and RET51, which differ in the number of their C-terminal amino acids. RET isoforms are ... -
Evaluation of the determinants and characterization of bleeding in hemophilia A and B carriers
Hemophilia A and B are bleeding disorders caused by a deficiency in coagulation factor VIII (FVIII) or coagulation factor IX (FIX), respectively. Due to the X-linked inheritance pattern, males are affected with the disease, ... -
Early mechanisms of factor VIII immunity in hemophilia A
The most serious complication in treating hemophilia A (HA) is the development of an immune response to the therapeutically-administered factor VIII (FVIII). A better understanding of initiating events leading to FVIII ... -
The Role of TET2 in Macrophage Differentiation and Polarization
The epigenetic regulator Tet methylcytosine dioxygenase 2 (TET2) catalyzes the conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), leading to DNA demethylation. Inactivating TET2 mutations are common ... -
Regulation of HC11 Mouse Mammary Epithelial Cell Differentiation by the Rac/Stat3 axis
Studying cellular differentiation can reveal valuable information underlying the mechanisms that mediate cell fate. The HC11 mouse mammary epithelial cell line has long been used as a model to study lactogenic differentiation ... -
Roles of the Immune Cytokine Environment on Clonal Growth of Murine and Human Tet2 Mutant Bone Marrow Progenitors: Implications for Myelodysplastic Syndromes
TET2 is a tumor suppressor gene that has been implicated in the epigenetic regulation of gene expression. Inactivating TET2 mutations are common in MDS. These mutations may contribute to early clonal dominance and myeloid ... -
Kinome-wide CRISPR-Cas9 screen to identify kinases involved in Taxol resistance in breast cancer
(2016-08-31)Breast cancer is the most frequently diagnosed cancer in women, accounting for over 25% of cancer diagnoses and 13% of cancer-related deaths in Canadian women. There are many types of therapies for treatment or management ... -
Characterization of ALDH1A1 as a novel tumorigenic target mediating TAZ-induced lung tumorigenesis and stem cell phenotypes
(2016-08-24)Recent studies suggest that lung cancer stem cells (CSCs) may play major roles in lung cancer development, metastasis and drug resistance. Therefore, identification of lung CSC drivers may provide promising targets for ... -
Investigating the Role of cAMP-Signaling in the Regulation of Vascular Endothelial Cell Adaptive Responses to Fluid Shear Stress
(2016-05-11)The circulating blood exerts a force on the vascular endothelium, termed fluid shear stress (FSS), which directly impacts numerous vascular endothelial cell (VEC) functions. For example, high rates of linear and undisturbed ... -
The effect of biomechanical and biochemical regulators on the expression of Factor VIII and von Willebrand Factor in endothelial cells
(2016-01-29)The coagulant protein Factor VIII (FVIII) has been the subject of much debate and controversy regarding where, when, and how it is expressed and produced in the human body for much of the past 30-40 years. Expression was ... -
EVALUATION OF THE AGE-RELATED PATHOPHYSIOLOGY OF VON WILLEBRAND FACTOR
(2016-01-20)von Willebrand Factor (VWF) is a plasma multimeric glycoprotein involved in platelet adhesion and aggregation at sites of vascular injury, and the carrier for coagulation Factor VIII (FVIII). Levels of VWF are influenced ... -
Exploring the regulation of YAP and TAZ in antitubulin drug response and mammary tumorigenesis
(2015-12-22)TAZ and YAP are transcriptional coactivators negatively regulated in the tumor suppressor (TS) Hippo pathway. TAZ and YAP play essential roles in tumorigenesis, epithelial mesenchymal transition (EMT) as well as cell ... -
ROLE OF AMPLIFICATION OF CHROMOSOME 6P12-P21 IN HUMAN OSTEOSARCOMA
(2015-12-16)Osteosarcoma is an aggressive bone malignancy with neither reliable prognostic or predictive biomarkers nor drugs for targeted therapy. It is the most common malignant tumour of bone, predominantly occurring in adolescents. ... -
RAD9A STABILIZATION AND DESTABILIZATION PROCESSES IN CHECKPOINT MAINTENANCE AND CHECKPOINT RECOVERY
(2015-11-30)The phosphorylation of the sensor-checkpoint Rad9A is essential for Chk1 activation in S-phase and during the G2/M checkpoints. Previous studies have demonstrated a late phosphorylation of Rad9A after DNA damage. Rad9A ... -
VALIDATION OF THE SELF-BAT (SELF-ADMINISTERED BLEEDING ASSESSMENT TOOL) AND EVALUATION OF DETERMINANTS OF HEALTH IN HEMOPHILIA CARRIERS
(2015-11-18)Hemophilia A and B are X-linked deficiencies of coagulation factor VIII and IX respectively. Males are affected, while females are carriers of the disease. Recently, it has become clear that more than a third of hemophilia ... -
MOLECULAR CHARACTERIZATION OF GLEASON PATTERNS 3 AND 4 PROSTATE CANCER USING REVERSE WARBURG EFFECT-ASSOCIATED GENES
(2015-11-16)Background: Gleason scores (GS) 3+3 and 3+4 prostate cancers (PCa) differ greatly in their clinical courses, with Gleason pattern (GP) 4 representing a major independent risk factor for cancer progression. However, GP ... -
Characterizing angiodysplasia in type 2 von Willebrand disease (VWD) using blood outgrowth endothelial cells (BOECs)
(2015-10-03)Gastrointestinal bleeding associated with angiodysplasia is a common, often intractable complication in patients with von Willebrand disease (VWD). von Willebrand factor (VWF), the protein deficient in VWD, was recently ... -
Investigations into the Plasma Membrane Trafficking of Multidrug Resistance Protein 4 (ABCC4/MRP4)
(2015-09-10)Multidrug resistance protein 4 (MRP4) is a member of subfamily C of the ATP-binding cassette superfamily of membrane transport proteins. In polarized cells, MRP4 localizes to the apical or basolateral plasma membrane ...
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