Browsing Pathology and Molecular Medicine, Department of by Title
Now showing items 41-60 of 123
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Functional analysis of single nucleotide polymorphisms in the proximal promoter regions of the multidrug transporter genes MRP1/ABCC1 and MRP4/ABCC4
(2007-09-28)The ATP-binding cassette (ABC) transporter superfamily consists of 49 members, to which both Multidrug Resistance Protein 1 (MRP1/gene symbol: ABCC1) and MRP4 (ABCC4) belong. Single nucleotide polymorphisms (SNPs) in drug ... -
Functional consequences of the direct physical interaction between E2A transcription factors and CBP/p300
(2007-10-01)The E2A locus is involved in chromosomal translocations associated with acute lymphoblastic leukemia. The most common of these involves a translocation between chromosomes 1 and 19 (t1;19), resulting in expression of the ... -
Functional Interrogation of microRNA-375 in Merkel Cell Carcinoma
(2013-08-15)Merkel cell carcinoma (MCC) is a rare but highly aggressive neuroendocrine cutaneous cancer whose molecular biology is poorly characterized. Our broad research objective is to identify microRNAs (miRNA) that are biologically ... -
FVIII Immunity : early events and tolerance mechanisms to FVIII
(2008-08-15)Among the complications of current treatments for hemophilia A, the development of anti-FVIII antibodies including “FVIII inhibitors” remains the major clinical problem in treating hemophiliacs. Factor VIII inhibitors work ... -
Generation and Optimization of the Self-Administered Bleeding Assessment Tool
(2013-05-02)Defects in haemostasis, specifically in the quantitative or qualitative properties of von Willebrand factor (VWF), result in the most commonly inherited bleeding disorder, von Willebrand disease (VWD). Of the three types ... -
Genomic Characterization of Recurrent Chromosomal Aberrations in Retinoblastoma
(2010-10-19)Retinoblastoma is the second most common childhood intraocular malignancy and development of the tumour is initiated by bi-allelic loss of the RB1 gene. Bi-allelic RB1 loss may not always directly lead to malignant ... -
Identification and characterization of E2A-PBX1 genomic binding sites using ChIP-seq and bioinformatics
(2014-07-16)A translocation between chromosomes 1 and 19, referred to as t(1;19), results in expression of the chimeric, oncogenic transcription factor E2A-PBX1 in cases of B-progenitor acute lymphoblastic leukemia. Previous studies ... -
Identification and characterization of transcriptional targets of TAZ in human breast cancer
TAZ is a transcriptional co-activator and an effector of the Hippo signaling pathway. Since its discovery in 2000, we have gained tremendous insights into the roles TAZ plays in development and disease. TAZ acts as an ... -
Identification and characterization of ΔNp63 as a novel transcriptional target negatively regulated by TAZ in mammary tumorigenesis
(2014-08-25)The transcriptional co-activator with PDZ-binding domain (TAZ) is a key downstream component of the Hippo pathway that plays important roles in animal size control, stem cell renewal, differentiation and tumorigenesis. We ... -
The Identification of BRCA1 and BRCA2 Mutation Carriers Using Functional Genomic Assays
(2009-04-14)An estimated 5-10% of breast cancers are hereditary in nature and are due to the presence of a mutation in a breast cancer predisposition gene; approximately half of these cases possess a mutation in BRCA1 or BRCA2. Many ... -
Identification of Novel Proteins Interacting with LATS1/2 During Tumorigenesis and Anti-Tubulin Drug Response
The Hippo pathway is a signaling cascade that plays essential roles in organisms such as development, organ size control, stem cell differentiation and renewal, as well as important processes necessary for cancer development ... -
Identification of Novel Receptor Tyrosine Kinases Regulating the Hippo Pathway in Cancer Cells
Several studies have shown that the Hippo pathway plays an important role in tissue growth, organ size control, and cell death. Deregulation of the Hippo pathway contributes to loss of cell contact inhibition and continuing ... -
Identifying a Prognostic Test in Follicular Lymphoma Using a Tissue Microarray and Immunohistochemistry
(2008-07-08)Follicular lymphoma (FL) is an attractive model for discovering biomarkers and elucidating mechanisms of tumour progression. We hypothesized that alterations in the expression of proteins with known roles in cancer biology ... -
Identifying the Molecular Mechanism of TAZ-Induced Lung Tumorigenesis
(2014-09-17)The transcriptional co-activator with PDZ-binding domain (TAZ) is a transcriptional co-activator and downstream component of the tumor suppressor Hippo pathway that plays critical roles in organ size control, stem cell ... -
An immune modulatory role for the fes proto-oncogene
(2015-07-21)The Fes protein tyrosine kinase is abundantly expressed in phagocytic immune cells, including tumor associated macrophages. Fes knockout mice (fes-/-) display enhanced sensitivity to LPS, and this was shown to be associated ... -
Impact of Androgen Deprivation Therapy on the Gastrointestinal Microbiota of Prostate Cancer Patients
Background: Prostate Cancer (PCa) is one of the leading causes of cancer in men. Androgen deprivation therapy (ADT), the standard of care for advanced PCa, has been associated with developing the metabolic syndrome. The ... -
In Vitro Characterization of the Function of ABCA1: Effects of Naturally Occurring Mutations
(2010-02-12)The ATP-binding cassette (ABC) transporter, ABCA1, plays a pivotal role in reverse cholesterol transport, which is the elimination of excess sterols from peripheral cells and their transport to the liver for elimination. ... -
The Influence of Sequence Variation on von Willebrand Factor Biosynthesis, Proteolytic Processing and Clearance
(2012-08-07)Von Willebrand factor (VWF) promotes platelet adhesion and aggregation at sites of vascular damage. This function is directly related to the multimer size of VWF. The VWF-specific metalloprotease ADAMTS13 decreases VWF ... -
Integrating Phospholipid and Cyclic Nucleotide Signaling: Roles of Phosphodiesterases as Enzymes and Tethers
(2011-06-28)Cells of the cardiovascular system translate incoming extracellular signals from hormones and drugs through binding of cell surface receptors, and activation of intracellular signaling cascades allowing modulation of ...