Browsing Pathology and Molecular Medicine, Department of by Title
Now showing items 61-80 of 124
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Integrating Phospholipid and Cyclic Nucleotide Signaling: Roles of Phosphodiesterases as Enzymes and Tethers
(2011-06-28)Cells of the cardiovascular system translate incoming extracellular signals from hormones and drugs through binding of cell surface receptors, and activation of intracellular signaling cascades allowing modulation of ... -
Investigating the Genetic Basis of Type 3 of Von Willebrand Disease (VWD)
(2013-10-18)von Willebrand Disease (VWD) is the most common inherited bleeding disorder in humans, resulting from quantitative or qualitative deficiencies of von Willebrand factor (VWF). Type 3 VWD is the rarest and most severe form ... -
Investigating the relationship between the RET receptor, Cbl and ARHGEF7 in downregulation of RET
(2008-07-15)The RET proto-oncogene encodes a receptor tyrosine kinase (RTK), with two major isoforms, RET9 and RET51, which differ in their C-termini, and therefore recruit different signaling complexes. RET plays an important role ... -
Investigating the Role of cAMP-Signaling in the Regulation of Vascular Endothelial Cell Adaptive Responses to Fluid Shear Stress
(2016-05-11)The circulating blood exerts a force on the vascular endothelium, termed fluid shear stress (FSS), which directly impacts numerous vascular endothelial cell (VEC) functions. For example, high rates of linear and undisturbed ... -
Investigating the role of PDE4D7 in vascular smooth muscle cell migration
(2015-08-31)Inhibiting the maladaptive migration of vascular smooth muscle cells (VSMCs) in injured blood vessels can help to reduce the development of intimal lesions in vascular diseases such as atherosclerosis and restenosis. Cyclic ... -
Investigating the role of von Willebrand factor (VWF) in angiogenesis
Gastrointestinal bleeding from angiodysplasia can be a debilitating problem for patients with defective or deficient von Willebrand factor (VWF). Studies have pointed to a regulatory role for VWF in vessel formation however, ... -
Investigation of Private Well Water Quality in Southeastern Ontario Using Geographic Information Systems and Molecular Microbial Source Tracking Tools
(2014-06-02)In Canada, as in many other affluent nations, private well water consumers remain at risk for gastrointestinal (GI) illness due to fecal contamination of groundwater. There have been numerous documented outbreaks of GI ... -
Investigations into the Plasma Membrane Trafficking of Multidrug Resistance Protein 4 (ABCC4/MRP4)
(2015-09-10)Multidrug resistance protein 4 (MRP4) is a member of subfamily C of the ATP-binding cassette superfamily of membrane transport proteins. In polarized cells, MRP4 localizes to the apical or basolateral plasma membrane ... -
Itch E3 ubiquitin ligase regulates LATS1 tumour suppressor stability
(2011-04-27)The Large Tumor Suppressor 1 (LATS1) is a serine/threonine kinase and tumor suppressor found down-regulated in a broad spectrum of human cancers. It is a central player of the emerging Hippo-LATS tumour suppressor pathway, ... -
Kinome-wide CRISPR-Cas9 screen to identify kinases involved in Taxol resistance in breast cancer
(2016-08-31)Breast cancer is the most frequently diagnosed cancer in women, accounting for over 25% of cancer diagnoses and 13% of cancer-related deaths in Canadian women. There are many types of therapies for treatment or management ... -
The Mammary Epithelial Cell-Specific Role of Peroxisome Proliferator-Activated Receptor (PPAR)γ in DMBA-Mediated Breast Tumourigenesis
(2008-09-04)Breast cancer is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths, among women world-wide. Improved understanding of breast tumourigenesis may facilitate the development of more ... -
The Mammary Epithelial Contribution Of PPARγ In Breast Tumourigenesis
(2014-08-06)Previous studies with peroxisome proliferator-activated receptor (PPAR)γ heterozygous mice suggest PPARγ normally suppresses 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast tumour progression, but the mechanisms and ... -
Mapping and Antagonizing the Interaction Between Phosphodiesterase 3B and Exchange Protein Activated by cAMP-1 Elucidates Their Roles in Endothelial Cell Adhesion
(2009-10-07)The ubiquitous second messenger cAMP acts to integrate and translate information encoded by extracellular messenger molecules, including hormones and neurotransmitters. Intracellular cAMP concentrations are regulated through ... -
Metabolic features of prostate malignancy
Altered metabolism is an inherent property of cancer and provides a rich opportunity for exploring its underlying biology and developing diagnostic biomarkers. We used desorption electrospray ionization mass spectrometry ... -
MicroRNA-193B Functions as a Tumor Suppressor in Malignant Melanoma
(2012-05-31)Cutaneous melanoma is an increasingly common skin cancer characterized by aggressive metastatic growth and poor prognosis. The mechanisms behind melanoma progression are not fully understood, but emerging evidence suggests ... -
MicroRNA-205 Involvement in Cutaneous Melanoma
(2012-07-09)Cutaneous melanoma is an increasingly common aggressive malignancy. The molecular mechanisms responsible for melanoma’s initiation and progression are still unclear, but new evidence suggests microRNAs (miRNAs) may be ... -
Modulation of Human Multidrug Resistance Proteins by Reactive Quinone-based Glutathione Conjugates
(2015-02-17)The multidrug resistance protein 1 (MRP1) and MRP2 mediate the ATP-dependent cellular efflux of a diverse set of organic molecules including many glutathione (GSH) conjugates. In the present study, a series of GSH conjugated ... -
Molecular Characterization of Gleason Patterns 3 and 4 Prostate Cancer Using Reverse Warburg Effect-Associated Genes
(2015-11-16)Background: Gleason scores (GS) 3+3 and 3+4 prostate cancers (PCa) differ greatly in their clinical courses, with Gleason pattern (GP) 4 representing a major independent risk factor for cancer progression. However, GP ... -
Molecular Characterization of Human Homologs of Yeast MOB
(2008-09-24)MOB (Mps One Binder) is a conserved gene family found in all major kingdoms. The MOB genes are essential components acting in mitotic exit and cytokinesis in both budding and fission yeasts. They are further identified as ... -
The molecular mechanism of TAZ-induced mammary tumorigenesis
(2013-08-02)TAZ (Transcriptional co-activator with PDZ-binding motif) is a WW-domain containing protein recently identified as a downstream component of the Hippo tumor suppressor pathway and mediator of biologically important processes ...