Browsing Pathology and Molecular Medicine, Department of by Title
Now showing items 111-118 of 118
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The Thrombogenic Influences of Factor VIII and von Willebrand Factor
(2015-04-02)von Willebrand factor (VWF) and factor VIII (FVIII) circulate in the blood as a non-covalent complex. VWF plays an important role in primary hemostasis through its interactions with components of the extracellular matrix ... -
Tolerance Induction and The Immunobiology of Factor VIII in Hemophilia A
(2010-09-29)The development of inhibitory antibodies to the factor VIII (FVIII) protein is the greatest complication in the management of hemophilia A patients. These antibodies, which form in approximately 25% of patients, neutralize ... -
TOWARDS A B-LYMPHOID MODEL OF E2A-PBX1-MEDIATED LEUKEMOGENESIS: EVALUATING THE IMPACT OF HEMATOPOIETIC CELL OF ORIGIN ON THE TRANSFORMATION PROPERTIES OF A LEUKEMOGENIC TRANSCRIPTION FACTOR
(2013-09-03)The t(1;19) chromosomal translocation is present in 5% of acute lymphoblastic leukemia (ALL) cases and leads to expression of the oncogenic transcription factor, E2A-PBX1. Although t(1;19) is exclusively associated with ... -
Understanding the Hippo-LATS pathway in tumorigenesis
(2011-09-26)The Hippo-LATS signaling pathway originally identified in Drosophila is conserved in mammalian systems and serves essential roles in mediating size control as well as tumorigenesis. In humans, the core kinase cassette ... -
Using Small Molecules to Inhibit an E2A-PBX1:CBP Interaction Involved in Acute Lymphoblastic Leukemia
(2009-09-03)E2A-PBX1 is expressed as a consequence of a recurring chromosomal translocation seen in 5% of acute lymphoblastic leukemia cases. We recently reported that substitution of a leucine residue (L20A) within the N-terminal ... -
Utilizing Caenorhabditis elegans as a novel platform to model human RET receptor function
(2015-02-17)In this study, we report a novel use of Caenorhabditis elegans as a platform to model the function of human RET isoforms, RET9 and RET51. C. elegans does not encompass an orthologue of RET. Thus, we ectopically expressed ... -
Validation of a Gene-Expression Based Assay for BRCA1 Function
(2013-09-26)Breast cancer is a disease that afflicts a significant proportion of women globally. 5-10% of breast cancer cases are linked to inherited polymorphisms in critical genes such as BRCA1, a tumour suppressor essential for ... -
VALIDATION OF THE SELF-BAT (SELF-ADMINISTERED BLEEDING ASSESSMENT TOOL) AND EVALUATION OF DETERMINANTS OF HEALTH IN HEMOPHILIA CARRIERS
(2015-11-18)Hemophilia A and B are X-linked deficiencies of coagulation factor VIII and IX respectively. Males are affected, while females are carriers of the disease. Recently, it has become clear that more than a third of hemophilia ...