Browsing Pathology and Molecular Medicine, Department of by Subject "EPAC"
Now showing items 1-2 of 2
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Mapping and Antagonizing the Interaction Between Phosphodiesterase 3B and Exchange Protein Activated by cAMP-1 Elucidates Their Roles in Endothelial Cell Adhesion
(2009-10-07)The ubiquitous second messenger cAMP acts to integrate and translate information encoded by extracellular messenger molecules, including hormones and neurotransmitters. Intracellular cAMP concentrations are regulated through ... -
Protein Kinase A, Exchange Protein Activated By cAMP 1, and Phosphodiesterase 4D All Associate With VE-Cadherin to Regulate Endothelial Barrier Function
(2007-09-17)Vascular endothelial cells (VECs) play an essential role in regulating the passage of macromolecules and cells between the blood stream and underlying tissues. The second messenger 3’, 5’ cyclic adenosine monophosphate ...