Browsing Pathology and Molecular Medicine, Department of by Author "Mueller, Christopher"
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Molecular Stress Signaling in Breast Epithelial Cells
Antonova, Lilia (2008-01-15)Breast cancer is a complex disease, whose etiology is not well understood. A number of factors have been found to contribute to its development. Psychological stress has been recognized as such a factor in epidemiological ... -
THE NRF-1/GABP/BRCA1 Transcriptional Network in Mammary Epithelial Differentiation
Thompson, Crista (2012-09-11)Evidence indicates that the mammary epithelium is arranged in a hierarchy in which mature luminal and myoepithelial cells are derived from stem cells through a series of lineage-restricted intermediates. One of the more ... -
Regulation of the Glucocorticoid Receptor Promoter and Its Prognostic Value in Tamoxifen-Treated ER+ Breast Cancer
Snider, HilaryMost breast cancers are estrogen receptor positive (ER+) and therefore benefit from endocrine-based therapies such as tamoxifen which impair estrogen signaling. However, resistance is a major clinical concern and ER status ... -
The Role of ALDH1A3 in Normal and Transformed Mammary Gland Development
Cull, Alyssa (2012-09-27)Aldehyde dehydrogenases (ALDHs) have been used as stem cell markers in a variety of tissues, including the breast. However, it is currently unknown whether ALDH family members participate in normal mammary development or ...