Browsing Pathology and Molecular Medicine, Department of by Author "Mulligan, Lois"
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Characterizing the Role of the RET Receptor Tyrosine Kinase in Colorectal Cancer
Maritan, SarahRET is a receptor tyrosine kinase (RTK) that plays important roles in both normal development and cancer. RET has well-established oncogenic roles in thyroid cancer and growing evidence implicates RET activity in the ... -
Differential Contributions of RET-isoforms to Tumour Invasion
Lian, EricRET is a receptor tyrosine kinase (RTK) which is normally activated at the cell surface by glial cell line-derived neurotrophic factors and plays critical roles during embryogenesis. RET is expressed as two protein isoforms, ... -
Differential Trafficking of RET Receptor Tyrosine Kinase Isoforms
Crupi, MathieuThe RET receptor tyrosine kinase is implicated in both normal development and cancer. RET is expressed as two protein isoforms, RET9 and RET51, which differ in the number of their C-terminal amino acids. RET isoforms are ... -
Evaluating the relationship between the RET receptor tyrosine kinase and TMEM127
Rekab, AishaPheochromocytomas (PCC) are highly heritable neoplasms of the adrenal gland, carrying germline mutations in approximately 40% of cases. PCC susceptibility genes have been subdivided into two clusters: hypoxia-related genes, ...