Browsing Pathology and Molecular Medicine, Department of by Author "Raptis, Leda"
Now showing items 1-7 of 7
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Novel mechanisms of Stat3 activation
Arulanandam, Rozanne (2010-02-23)Stat3 (signal transducer and activator of transcription-3) is activated by a number of receptor and non-receptor tyrosine kinases, while a constitutively active form of Stat3 alone is sufficient to induce neoplastic ... -
Regulation of HC11 Mouse Mammary Epithelial Cell Differentiation by the Rac/Stat3 axis
Niit, MaximilianStudying cellular differentiation can reveal valuable information underlying the mechanisms that mediate cell fate. The HC11 mouse mammary epithelial cell line has long been used as a model to study lactogenic differentiation ... -
The Role of Cadherin-11 and gp130 in Transformation by Activated Src
D'Abreo, Carmeline (2011-11-29)Signal Transducer and Activator of Transcription 3, Stat3, has been associated with cytokine-induced proliferation, anti-apoptosis and neoplastic transformation, while constitutively active Stat3 has been found in many ... -
The Role of Stat3 in Adipocytic Differentiation
Sopik, Victoria (2014-09-27)Cellular proliferation is often regulated in conjunction with differentiation. It is important to investigate the mechanisms underlying cellular differentiation and proliferation, because defects in their control can ... -
The role of Stat3 in cell division and apoptosis
Anagnostopoulou, Aikaterini (2009-04-27)The Signal Transducer and Activator of Transcription-3 (Stat3) is a transcription factor that is required for transformation by a number of oncogenes, while a constitutively active form of Stat3 alone is sufficient to ... -
Role of the Cadherin-11/Rac1/Stat3 Axis in Src-Mediated Transformation and in Adipocytic Differentiation
Guy, StephanieStat3 (signal transducer and activator of transcription-3) is activated by phosphorylation on tyrosine-705 (Stat3-ptyr705) downstream of cytokines, growth factors, and oncogenes. Our lab has demonstrated that engagement ... -
The Src/Stat3 axis in Met signaling in human invasive breast cancer: a potential predictive marker
Carefoot, Esther (2014-01-24)Met has been found to be over-expressed in human breast cancer, correlating with disease progression and poor prognosis. Src and Stat3 have also been found to be over-expressed in many human cancers, including breast. Met, ...