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Tolerance Induction and The Immunobiology of Factor VIII in Hemophilia A
The development of inhibitory antibodies to the factor VIII (FVIII) protein is the greatest complication in the management of hemophilia A patients. These antibodies, which form in approximately 25% of patients, neutralize ...
The effect of biomechanical and biochemical regulators on the expression of Factor VIII and von Willebrand Factor in endothelial cells
The coagulant protein Factor VIII (FVIII) has been the subject of much debate and controversy regarding where, when, and how it is expressed and produced in the human body for much of the past 30-40 years. Expression was ...
Endothelial cell synthesis of Factor VIII
Factor VIII (FVIII) is an essential blood-clotting protein and mutations in the FVIII gene are the cause of hemophilia A, a severe inherited bleeding disorder. FVIII synthesis has been observed in discreet endothelial ...
The Thrombogenic Influences of Factor VIII and von Willebrand Factor
von Willebrand factor (VWF) and factor VIII (FVIII) circulate in the blood as a non-covalent complex. VWF plays an important role in primary hemostasis through its interactions with components of the extracellular matrix ...
The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF-dependent and independent manner
Essentials CLEC4M is an endocytic receptor for factor FVIII. CLEC4M interacts with FVIII in a VWF-dependent and independent manner. CLEC4M binds to mannose-containing glycans on FVIII. CLEC4M internalization of FVIII ...