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    Identification and characterization of E2A-PBX1 genomic binding sites using ChIP-seq and bioinformatics 

    Nanan, Kyster (2014-07-16)
    A translocation between chromosomes 1 and 19, referred to as t(1;19), results in expression of the chimeric, oncogenic transcription factor E2A-PBX1 in cases of B-progenitor acute lymphoblastic leukemia. Previous studies ...
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    Using Small Molecules to Inhibit an E2A-PBX1:CBP Interaction Involved in Acute Lymphoblastic Leukemia 

    Purvis, Amelia (2009-09-03)
    E2A-PBX1 is expressed as a consequence of a recurring chromosomal translocation seen in 5% of acute lymphoblastic leukemia cases. We recently reported that substitution of a leucine residue (L20A) within the N-terminal ...
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    Examining the effect of CBP on the E2A-PBX1 and HOXB4 interaction 

    Menezes, Sean Christopher (2008-09-29)
    The E2A-PBX1 fusion gene results from the t(1;19) chromosomal translocation that is found in 25% of pre-B-cell cases of acute lymphoblastic leukemia (ALL). The resulting encoded product contains the transactivation domains ...
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    Functional consequences of the direct physical interaction between E2A transcription factors and CBP/p300 

    Hyndman, Brandy Dawn (2007-10-01)
    The E2A locus is involved in chromosomal translocations associated with acute lymphoblastic leukemia. The most common of these involves a translocation between chromosomes 1 and 19 (t1;19), resulting in expression of the ...
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    Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor 

    Woodcroft, Mark (2013-09-03)
    The t(1;19) chromosomal translocation is present in 5% of acute lymphoblastic leukemia (ALL) cases and leads to expression of the oncogenic transcription factor, E2A-PBX1. Although t(1;19) is exclusively associated with ...

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    AuthorHyndman, Brandy Dawn (1)Menezes, Sean Christopher (1)Nanan, Kyster (1)Purvis, Amelia (1)Woodcroft, Mark (1)Subject
    Leukemia (5)
    E2A-PBX1 (2)Acetylation (1)Acute Lymphoblastic Leukemia (1)Bioinformatics (1)Cancer Biology (1)CBP (1)Chromosomal translocations (1)Epigenetics (1)Fluorescence Anisotropy (1)... View MoreDate Published2009 (1)2008 (1)2007 (1)

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