• Login
    View Item 
    •   Home
    • Graduate Theses, Dissertations and Projects
    • Queen's Graduate Theses and Dissertations
    • View Item
    •   Home
    • Graduate Theses, Dissertations and Projects
    • Queen's Graduate Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Colorectal cancer diagnostic pathways in Ontario

    Thumbnail
    View/Open
    Guan_Zhen_201812_MSC.pdf (2.717Mb)
    Author
    Guan, Zhen
    Metadata
    Show full item record
    Abstract
    Purpose: The purpose of this study was to differentiate diagnostic pathways in colorectal cancer in Ontario through the development of a pathway categorization scheme, and evaluate the patient-, disease-, system-related characteristics of patients and the length of the diagnostic interval across the diagnostic pathway categories.

    Methods: This was a cross-sectional study using an existing cohort at ICES. The study population included patients who were diagnosed with colorectal cancer in Ontario between 2009 and 2012. Cluster analysis used eleven variables that were related to patient presentation, patient visit pattern, patient symptom pattern and referral process to characterize and categorize diagnostic pathways. Chi-square test and One-way ANOVA were used to assess the association between the examined factors (age, sex, material deprivation quintile, comorbidities, and stage) and the diagnostic pathway categorization scheme. Unadjusted quantile regression was used to assess the association between the diagnostic interval length and the diagnostic pathway categorization scheme.

    Results: Six distinct diagnostic pathways were identified: asymptomatic pathway (N=4,494), colonoscopy pathway (N=10,066), the imaging and colonoscopy pathway (N=3,427), imaging alone pathway (N=2,238), the imaging and emergency presentation pathway (N=2,849) and no pre-diagnostic workup pathway (N=887). Patients who went through a pathway that was more adherent to diagnostic pathway guidelines (eg. asymptomatic pathway) were more likely to be younger, healthier and living in less deprived areas, and they tended to be diagnosed at an early stage with a short diagnostic interval. Patients who were female, older, living in more deprived areas and with more comorbid disease were more likely to go through pathways that were divergent from those guidelines. The length of the diagnostic interval was correlated to the

    number of colorectal cancer diagnosis-related visits occurring during the interval. All examined factors and the diagnostic interval were significantly associated with the pathway categorization (p<0.0001).

    Conclusions: This study demonstrated substantial variations in colorectal cancer diagnostic pathways in Ontario. Interventions should be designed to provide individualized and more effective diagnostic services to patients.
    URI for this record
    http://hdl.handle.net/1974/25886
    Collections
    • Department of Public Health Sciences Graduate Theses
    • Queen's Graduate Theses and Dissertations
    Request an alternative format
    If you require this document in an alternate, accessible format, please contact the Queen's Adaptive Technology Centre

    DSpace software copyright © 2002-2015  DuraSpace
    Contact Us
    Theme by 
    Atmire NV
     

     

    Browse

    All of QSpaceCommunities & CollectionsPublished DatesAuthorsTitlesSubjectsTypesThis CollectionPublished DatesAuthorsTitlesSubjectsTypes

    My Account

    LoginRegister

    Statistics

    View Usage StatisticsView Google Analytics Statistics

    DSpace software copyright © 2002-2015  DuraSpace
    Contact Us
    Theme by 
    Atmire NV