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dc.contributor.authorMiron, Caitlin E.en
dc.contributor.authorPetitjean, Anneen
dc.date.accessioned2019-05-30T19:40:18Z
dc.date.available2019-05-30T19:40:18Z
dc.date.issued2018-04-24
dc.identifier.urihttp://hdl.handle.net/1974/26258
dc.description.abstractThe recognition of non-canonical DNA and RNA architectures such as guanine quadruplexes by small molecule ligands has become a promising strategy for anticancer and antiviral applications in recent years, leading to an exponential increase in the number of quadruplex ligands reported in the literature. There is consequently a need for “benchmark” compounds which can be used as controls to facilitate comparisons between novel and previously reported ligands. One candidate for this role is Phen-DC3, which binds with high affinity and selectivity to guanine quadruplexes. To encourage its use in this role, an alternate synthetic route for the production of Phen-DC3 that may be more appropriate for implementation on a large scale is reported. This pathway eliminates the need for several hazardous reagents and increases the overall synthetic yield from 21% to a maximum of 43%.en
dc.description.sponsorshipNSERC, CFI, Queen's Universityen
dc.language.isoenen
dc.publisherThieme Stuttgart-New Yorken
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry::Organic synthesisen
dc.titleAn Improved Route for the Synthesis of Guanine Quadruplex Liganden
dc.typejournal articleen
dc.identifier.doiDOI: 10.1055/s-0036-1591994


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