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dc.contributor.authorKhachatryan, Davit
dc.contributor.authorGroll, Dianne
dc.contributor.authorBooij, Linda
dc.contributor.authorSepehry, Amir Ali
dc.contributor.authorSchutz, Christian G.
dc.date.accessioned2019-07-17T15:56:06Z
dc.date.available2019-07-17T15:56:06Z
dc.date.issued2016-03
dc.identifier.urihttp://hdl.handle.net/1974/26401
dc.description.abstractOBJECTIVE: Posttraumatic stress disorder (PTSD) is a disorder with significant sleep morbidity and limited treatment options. Prazosin may constitute a novel management approach and has been tested recently in a number of trials. We conducted a meta-analysis to examine the effectiveness of prazosin for nightmares and other sleep disturbances in adults with PTSD. METHOD: A systematic review of databases for randomized, double-blind, placebo-controlled trials of adults diagnosed with PTSD and reporting sleep disturbances that were treated with prazosin was conducted in January 2015. No limitations were placed on language or year of publication. RESULTS: Six randomized controlled trials of prazosin for sleep disturbances in patients with PTSD were included (sample n=240). We found that prazosin was statistically significantly more effective than placebo in improving sleep quality [g=0.987, 95% confidence interval (CI): 0.324-1.651] and in reducing overall PTSD symptoms (g=0.699, 95% CI: 0.139-1.260) and sleep disturbances in particular (g=0.799, 95% CI: 0.391-1.234). CONCLUSIONS: Prazosin showed medium-to-large and statistically significant effects on PTSD symptoms in general and sleep disturbances in particular. While promising, results should be interpreted with caution given the limited total number of participants and the limitations induced by the majority of participants being male and noncivilian.en_US
dc.language.isoenen_US
dc.subjectPrazosinen_US
dc.subjectSleep Disturbanceen_US
dc.subjectNightmaresen_US
dc.subjectMeta-analysisen_US
dc.subjectPTSDen_US
dc.titlePrazosin for Treating Sleep Disturbances in Adults With Posttraumatic Stress Disorder: a Systematic Review and Meta-analysis of Randomized Controlled Trialsen_US
dc.typejournal articleen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.genhosppsych.2015.10.007


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